The influence of genetic and acquired factors on the vulnerability to develop depression: a review

被引：16

作者：

Zhang, Xingfang ^{[1
,2
,3
]}

Qiao, Yajun ^{[2
,4
,5
]}

Wang, Mengyuan

Liang, Xinxin ^{[2
,5
]}

Zhang, Ming ^{[2
,5
]}

Li, Cen ^{[2
,5
]}

Cairang, Jixian ^{[6
]}

Wang, Jianv ^{[2
,5
]}

Bi, Hongtao ^{[2
,5
]}

Gao, Tingting ^{[1
,4
]}

机构：

[1] Chengdu Med Coll, Sch Psychol, Chengdu 610500, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China

[3] Qinghai Univ, Coll Med, Xining 810001, Peoples R China

[4] Southern Med Univ, Peoples Hosp Jiangmen, Dept Psychiat, Jiangmen 529000, Peoples R China

[5] Chinese Acad Sci, Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810001, Peoples R China

[6] Tibetan Med Hosp Qinghai Prov, Dept Cardiovasc & Cerebrovasc, Xining 810007, Peoples R China

来源：

BIOSCIENCE REPORTS | 2023年 / 43卷 / 05期

基金：

中国博士后科学基金;

关键词：

MAJOR DEPRESSION; CHILDHOOD EXPERIENCES; SOCIAL-ISOLATION; MEDIATING ROLE; RISK-FACTORS; EARLY-ONSET; STRESS; ASSOCIATION; SYMPTOMS; ANXIETY;

D O I：

10.1042/BSR20222644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Depression is one of the most common mental disorders that affects hundreds of millions of people worldwide and has claimed tens of thousands of lives. The causes are divided into two main areas: congenital genetic factors and acquired environmental factors. Congenital factors include genetic mutations and epigenetic events; acquired factors include birth patterns, feeding patterns, dietary patterns, childhood experiences, education and economic levels, isolation due to epidemics, and many other complex factors. According to studies, these factors play important roles in depression. Therefore, here, we analyze and study the factors fromtwo aspects, describe their influence on individual depression, and analyze their underlying mechanisms. The results showed that both innate and acquired factors have significant effects on the occurrence of depressive disorder, and these findings may provide new ideas and methods for the study of depressive disorder, thus facilitating the process of depression prevention and treatment.

引用

页数：17

共 133 条

[1] Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples [J].