Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11

被引：3

作者：

Gregersen, Maja ^{[1
,2
,11
]}

Jepsen, Jens Richardt Mollegaard ^{[1
,2
,3
,4
,5
]}

Brandt, Julie Marie ^{[1
,2
,6
]}

Sondergaard, Anne ^{[1
,2
,6
]}

Rohd, Sinnika Birkehoj ^{[1
,2
]}

Veddum, Lotte ^{[2
,8
]}

Knudsen, Christina Bruun ^{[2
,7
]}

Andreassen, Anna Krogh ^{[2
,7
,8
]}

Burton, Birgitte Klee ^{[3
,6
,9
]}

Hjorthoj, Carsten ^{[2
,10
]}

Krantz, Mette Falkenberg ^{[3
]}

Greve, Aja Neergaard ^{[2
,7
,8
]}

Bliksted, Vibeke ^{[7
]}

Mors, Ole ^{[2
,7
,8
]}

Nordentoft, Merete ^{[1
,2
,6
]}

Thorup, Anne Amalie Elgaard ^{[2
,3
,6
]}

Hemager, Nicoline ^{[1
,2
,3
]}

机构：

[1] Mental Hlth Serv Capital Reg Denmark, CORE Copenhagen Res Ctr Mental Hlth, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[2] Lundbeck Fdn Initiat Integrat Psychiat Res iPSYCH, Aarhus, Denmark

[3] Mental Hlth Serv Capital Reg Denmark, Child & Adolescent Mental Hlth Ctr, Copenhagen, Denmark

[4] Mental Hlth Serv Capital Reg Denmark, Ctr Neuropsychiat Schizophrenia Res, Copenhagen, Denmark

[5] Mental Hlth Serv Capital Reg Denmark, Ctr Clin Intervent & Neuropsychiat Schizophrenia R, Copenhagen, Denmark

[6] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark

[7] Aarhus Univ, Fac Hlth & Med Sci, Dept Clin Med, Aarhus, Denmark

[8] Aarhus Univ Hosp Psychiat, Psychosis Res Unit, Skejby, Denmark

[9] Copenhagen Univ Hosp, Dept Child & Adolescent Psychiat, Psychiat Reg Zealand, Roskilde, Denmark

[10] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, Copenhagen, Denmark

[11] Gentofte Hospitalsvej 15,4th Floor, DK-2900 Hellerup, Denmark

来源：

SCHIZOPHRENIA BULLETIN | 2023年 / 49卷 / 06期

关键词：

Childhood; adolescence; subclinical psychosis; suicide risk behaviors; CROSS-NATIONAL ANALYSIS; 7-YEAR-OLD CHILDREN; PSYCHIATRIC-DISORDERS; PROTECTIVE FACTORS; META-REGRESSION; METAANALYSIS; SYMPTOMS; PREVALENCE; BEHAVIORS; THOUGHTS;

D O I：

10.1093/schbul/sbad052

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background and Hypothesis Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals. Study Design Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11). Study Results Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P = .03; OR 3.8, 95% CI, 1.3-11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups. Conclusions Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.

引用

页码：1602 / 1613

页数：12

共 69 条

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