Ultrahigh magnetic resonance contrast switching with water gated polymer-silica nanoparticles

被引：0
作者：
Yuan, Daohe [1 ]
Ellis, Connor M. [1 ]
Mozes, Ferenc E. [2 ]
Davis, Jason J. [1 ]
机构：
[1] Univ Oxford, Dept Chem, South Parks Rd, Oxford OX1 3QZ, England
[2] Univ Oxford, John Radcliffe Hosp, Oxford Ctr Clin Magnet Resonance Res, Radcliffe Dept Med, Level 0, Oxford OX3 9DU, England
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 40期
关键词：
POLY(METHACRYLIC ACID); RAFT POLYMERIZATION; CHEMICAL STRATEGY; RELAXIVITY; SURFACE; ENHANCEMENT; TRANSITION; MOLECULES; DIFFUSION; DYNAMICS;
D O I：
10.1039/d3cc01205k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Very high T-1 magnetic resonance imaging (MRI) switches can be obtained with pH-responsive polymer-coated paramagnetic mesoporous silica nanoparticles (MSNs), as the local environment traverses the pK(a) of the polymer coat (Delta r(1) similar to 50 mM(-1) s(-1) at 1.5 T and Delta r(1) similar to 22 mM(-1) s(-1) at 3 T). We assign these characteristics to a strong peripheral hydration capping at the mesopores, impacting channel-confined water mobility such that outer sphere contributions to contrast are greatly enhanced.
引用
收藏
页码：6008 / 6011
页数：4
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