Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders

被引：32

作者：

Agrawal, Kirti ^{[1
]}

Chakraborty, Pratik ^{[2
]}

Dewanjee, Saikat ^{[2
]}

Arfin, Saniya ^{[1
]}

Das, Sabya Sachi ^{[3
]}

Dey, Abhijit ^{[4
]}

Moustafa, Mahmoud ^{[5
,6
]}

Mishra, Prabhu Chandra ^{[7
]}

Jafari, Seid Mahdi ^{[8
,9
]}

Jha, Niraj Kumar ^{[7
]}

Jha, Saurabh Kumar ^{[7
,10
,11
]}

Kumar, Dhruv ^{[1
]}

机构：

[1] UPES Univ, Sch Hlth Sci & Technol, Dehra Dun 248007, Uttarakhand, India

[2] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, West Bengal, India

[3] DIT Univ, Sch Pharmaceut & Populat Hlth Informat, Dehra Dun 248009, Uttarakhand, India

[4] Presidency Univ, Dept Life Sci, Kolkata 700073, West Bengal, India

[5] King Khalid Univ, Fac Sci, Dept Biol, Abha, Saudi Arabia

[6] South Valley Univ, Fac Sci, Dept Bot & Microbiol, Qena, Egypt

[7] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India

[8] Gorgan Univ Agr Sci & Nat Resources, Dept Food Mat & Proc Design Engn, Gorgan, Iran

[9] Univ Vigo, Fac Sci, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, E-32004 Orense, Spain

[10] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India

[11] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2023年 / 144卷

关键词：

Anxiety; Depression; Neurodegenerative disorders; Psychological disorders (PLDs); Quercetin; Quercetin derivatives; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; CELL-DEATH; ANXIETY DISORDERS; INDUCED TOXICITY; AXIS FUNCTION; MOUSE MODEL; PC12; CELLS; IN-SILICO; BRAIN;

D O I：

10.1016/j.neubiorev.2022.104955

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Quercetin is a naturally occurring bioactive flavonoid abundant in many plants and fruits. Quercetin and its derivatives have shown an array of pharmacological activities in preclinical tests against various illnesses and ailments. Owing to its protective role against oxidative stress and neuroinflammation, quercetin is a possible therapeutic choice for the treatment of neurological disorders. Quercetin and its derivatives can modulate a variety of signal transductions, including neuroreceptor, neuroinflammatory receptor, and redox signaling events. The research on quercetin and its derivatives in neurology-related illnesses mainly focused on the targets, such as redox stress, neuroinflammation, and signaling pathways; however, the function of quercetin and its derivatives on specific molecular targets, such as nuclear receptors and proinflammatory mediators are yet to be explored. Findings showed that various molecular targets of quercetin and its derivatives have therapeutic potential against psychological and neurodegenerative disorders.

引用

页数：16

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