Multifunctional Biocatalysts for Organic Synthesis
被引:8
作者:
Thorpe, Thomas W.
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机构:
Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
Univ Edinburgh, Inst Quantitat Biol Biochem & Biotechnol IQB3, Alexander Crum Brown Rd,Kings Bldg, Edinburgh EH9 3FF, ScotlandUniv Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
Thorpe, Thomas W.
[1
,2
]
Marshall, James R.
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机构:
Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
Unilever Res Labs, Port Sunlight,Quarry Rd E, Bebington CH63 3JW, Wirral, EnglandUniv Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
Marshall, James R.
[1
,3
]
Turner, Nicholas J.
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机构:
Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, EnglandUniv Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
Turner, Nicholas J.
[1
]
机构:
[1] Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
[2] Univ Edinburgh, Inst Quantitat Biol Biochem & Biotechnol IQB3, Alexander Crum Brown Rd,Kings Bldg, Edinburgh EH9 3FF, Scotland
[3] Unilever Res Labs, Port Sunlight,Quarry Rd E, Bebington CH63 3JW, Wirral, England
Biocatalysis is becoming an indispensable tool in organic synthesis due to high enzymatic catalytic efficiency as well as exquisite chemo- and stereoselectivity. Some biocatalysts display great promiscuity including a broad substrate scope as well as the ability to catalyze more than one type of transformation. These promiscuous activities have been applied individually to efficiently access numerous valuable target molecules. However, systems in which enzymes possessing multiple different catalytic activities are applied in the synthesis are less well developed. Such multifunctional biocatalysts (MFBs) would simplify chemical synthesis by reducing the number of operational steps and enzyme count, as well as simplifying the sequence space that needs to be engineered to develop an efficient biocatalyst. In this Perspective, we highlight recently reported MFBs focusing on their synthetic utility and mechanism. We also offer insight into their origin as well as comment on potential strategies for their discovery and engineering.
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Das Sarma, Saikat
Pahari, Pallab
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机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Pahari, Pallab
Hazarika, Swapnali
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机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Hazarika, Swapnali
Hazarika, Parasa
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机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Hazarika, Parasa
Borah, Manash Jyoti
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h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Borah, Manash Jyoti
Konwar, Dilip
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机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
机构:
Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R ChinaFuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R China
Wang, Sibo
Wang, Xinchen
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Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R ChinaFuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R China
机构:
Nagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Mori, Shogo
Sakurai, Shu
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h-index: 0
机构:
Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Sakurai, Shu
Naka, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Deuterium Sci Res Unit, Sakyo Ku, Kyoto 6068501, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Naka, Hiroshi
Saito, Susumu
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机构:
Nagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Jiang, Guangde
Lu, Jingxia
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机构:
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Lu, Jingxia
Zhou, Megan
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机构:
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Zhou, Megan
Harrison, Wesley
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h-index: 0
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Harrison, Wesley
Zhao, Huimin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Das Sarma, Saikat
Pahari, Pallab
论文数: 0引用数: 0
h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Pahari, Pallab
Hazarika, Swapnali
论文数: 0引用数: 0
h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Hazarika, Swapnali
Hazarika, Parasa
论文数: 0引用数: 0
h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Hazarika, Parasa
Borah, Manash Jyoti
论文数: 0引用数: 0
h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
Borah, Manash Jyoti
Konwar, Dilip
论文数: 0引用数: 0
h-index: 0
机构:
CSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, IndiaCSIR, North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
机构:
Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R ChinaFuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R China
Wang, Sibo
Wang, Xinchen
论文数: 0引用数: 0
h-index: 0
机构:
Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R ChinaFuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350002, Peoples R China
机构:
Nagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Mori, Shogo
Sakurai, Shu
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Sakurai, Shu
Naka, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Deuterium Sci Res Unit, Sakyo Ku, Kyoto 6068501, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Naka, Hiroshi
Saito, Susumu
论文数: 0引用数: 0
h-index: 0
机构:
Nagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya 4648602, JapanNagoya Univ, Integrated Res Consortium Chem Sci IRCCS, Chikusa Ku, Nagoya 4648602, Japan
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Jiang, Guangde
Lu, Jingxia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Lu, Jingxia
Zhou, Megan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Zhou, Megan
Harrison, Wesley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Harrison, Wesley
Zhao, Huimin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USAUniv Illinois, Ctr Adv Bioenergy & Bioprod Innovat, Urbana, IL 61801 USA