Multifunctional Biocatalysts for Organic Synthesis

被引:8
作者
Thorpe, Thomas W. [1 ,2 ]
Marshall, James R. [1 ,3 ]
Turner, Nicholas J. [1 ]
机构
[1] Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Manchester M1 7DN, England
[2] Univ Edinburgh, Inst Quantitat Biol Biochem & Biotechnol IQB3, Alexander Crum Brown Rd,Kings Bldg, Edinburgh EH9 3FF, Scotland
[3] Unilever Res Labs, Port Sunlight,Quarry Rd E, Bebington CH63 3JW, Wirral, England
基金
欧洲研究理事会;
关键词
CATALYTIC PROMISCUITY; RADICAL CYCLIZATION; CASCADE; REDUCTION; EVOLUTION; ALCOHOLS; CARBENE; AMINES;
D O I
10.1021/jacs.3c09542
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biocatalysis is becoming an indispensable tool in organic synthesis due to high enzymatic catalytic efficiency as well as exquisite chemo- and stereoselectivity. Some biocatalysts display great promiscuity including a broad substrate scope as well as the ability to catalyze more than one type of transformation. These promiscuous activities have been applied individually to efficiently access numerous valuable target molecules. However, systems in which enzymes possessing multiple different catalytic activities are applied in the synthesis are less well developed. Such multifunctional biocatalysts (MFBs) would simplify chemical synthesis by reducing the number of operational steps and enzyme count, as well as simplifying the sequence space that needs to be engineered to develop an efficient biocatalyst. In this Perspective, we highlight recently reported MFBs focusing on their synthetic utility and mechanism. We also offer insight into their origin as well as comment on potential strategies for their discovery and engineering.
引用
收藏
页码:7876 / 7884
页数:9
相关论文
共 50 条
  • [11] Aluminium(III) chloride hexahydrate: an efficient and versatile reagent in organic synthesis
    Das Sarma, Saikat
    Pahari, Pallab
    Hazarika, Swapnali
    Hazarika, Parasa
    Borah, Manash Jyoti
    Konwar, Dilip
    ARKIVOC, 2013, : 243 - 263
  • [12] Multifunctional Metal-Organic Frameworks for Photocatalysis
    Wang, Sibo
    Wang, Xinchen
    SMALL, 2015, 11 (26) : 3097 - 3112
  • [13] Synthesis and applications of oxophosphonates in organic chemistry
    Atmani, Abdelkrim
    Memmou, Faiza
    Bouillon, Jean-Philippe
    COMPTES RENDUS CHIMIE, 2009, 12 (09) : 963 - 1001
  • [14] Electrochemical Organic Synthesis in Aqueous Media
    Li, MengFan
    Cheng, Xu
    ISRAEL JOURNAL OF CHEMISTRY, 2024, 64 (1-2)
  • [15] Bimetallic Covalent Organic Frameworks for Constructing Multifunctional Electrocatalyst
    Wu, Dekun
    Xu, Qing
    Qian, Jing
    Li, Xiaopeng
    Sun, Yuhan
    CHEMISTRY-A EUROPEAN JOURNAL, 2019, 25 (12) : 3105 - 3111
  • [16] Metal-Loaded Semiconductor-Photocatalysis of Alcohols for Selective Organic Synthesis: A Personal Account
    Mori, Shogo
    Sakurai, Shu
    Naka, Hiroshi
    Saito, Susumu
    SYNLETT, 2023, 34 (20) : 2361 - 2373
  • [17] Multifunctional Glucose Dehydrogenase Enabled Synthesis of Chiral-Bridged Bicyclic Nitrogen Heterocycles
    Jiang, Guangde
    Lu, Jingxia
    Zhou, Megan
    Harrison, Wesley
    Zhao, Huimin
    ACS CATALYSIS, 2024, 14 (09): : 7074 - 7079
  • [18] Applications of dialkylaminopyridine (DMAP) catalysts in organic synthesis
    Murugan, R
    Scriven, EFV
    ALDRICHIMICA ACTA, 2003, 36 (01) : 21 - 27
  • [19] Directed molecular evolution of biocatalysts
    Pompon, D
    ACTUALITE CHIMIQUE, 2002, (8-9): : 22 - 26
  • [20] An unsymmetrical covalent organic polymer for catalytic amide synthesis
    Yadav, Deepika
    Awasthi, Satish Kumar
    DALTON TRANSACTIONS, 2020, 49 (01) : 179 - 186