Post-Transplantation Cyclophosphamide-Based Graft-versusHost Disease Prophylaxis in HLA-Matched and Haploidentical Donor Transplantation for Patients with Hodgkin Lymphoma: A Comparative Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

被引：8

作者：

Montoro, Juan ^{[1
,2
]}

Boumendil, Ariane ^{[3
]}

Finel, Herve ^{[3
]}

Bramanti, Stefania ^{[4
]}

Castagna, Luca ^{[4
]}

Blaise, Didier ^{[5
]}

Dominietto, Alida ^{[6
]}

Kulagin, Aleksandr ^{[7
]}

Yakoub-Agha, Ibrahim ^{[8
]}

Tbakhi, Abdelghani ^{[9
]}

Solano, Carlos ^{[10
]}

Giebel, Sebastian ^{[11
]}

Gulbas, Zafer ^{[12
]}

Corral, Lucia Lopez ^{[13
]}

Perez-Simon, Jose A. ^{[14
]}

Martin, Jose Luis Diez ^{[15
]}

Sanz, Jaime ^{[1
]}

Farina, Lucia ^{[16
]}

Koc, Yener ^{[17
]}

Socie, Gerard ^{[18
]}

Arat, Mutlu ^{[19
]}

Jurado, Manuel ^{[20
]}

Bermudez, Arancha ^{[21
]}

Labussiere-Wallet, Helene ^{[22
]}

Villalba, Marta ^{[1
]}

Ciceri, Fabio ^{[23
]}

Martinez, Carmen ^{[24
]}

Nagler, Arnon ^{[25
]}

Sureda, Anna ^{[26
]}

Glass, Bertram ^{[27
]}

机构：

[1] Hosp Univ & Politecn La Fe, Dept Hematol, Av Fernando Abril Martorell 106, Valencia 46026, Spain

[2] Univ Catolica Valencia, Valencia, Spain

[3] European Soc Blood & Marrow Transplantat, Lymphoma Working Party, Paris, France

[4] IRCCS Humanitas Res Hosp, Dept Oncol Hematol, Milan, Italy

[5] Programme Transplantat & Therapie Cellulaire, Marseille, France

[6] IRCCS Osped Policlin San Martino, UO Ematol & Terapie Cellulari, Genoa, Italy

[7] Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia

[8] Univ Lille, CHU Lille, Lille, France

[9] King Hussein Canc Ctr, Amman, Jordan

[10] Hosp Clin Univ, Hematol Dept, INCLIVA, Valencia, Spain

[11] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Bone Marrow Transplantat & Oncohematol, Gliwice Branch, Gliwice, Poland

[12] Anadolu Hlth Ctr Avliated John Hopkins, Kocaeli, Gebze, Turkiye

[13] Hosp Clin Salamanca, Salamanca, Spain

[14] Univ Seville, Hosp Univ Virgen Rocio, Serv Hematol, Inst Biomed Sevilla IBIS,CSIC, Seville, Spain

[15] Hosp Gregorio Maranon, Madrid, Spain

[16] Univ Milan, Fdn IRCCS Ist Nazl Tumori Milano, Hematol Div, Milan, Italy

[17] Med Pk Hosp, Istanbul, Turkiye

[18] Dept Hematol BMT Hematol Transplantat, Paris, France

[19] Demiroglu Bilim Univ Istanbul, Florence Nightingale Hosp, Hematopoiet SCT Unit, Istanbul, Turkiye

[20] Hosp Virgen Nieves, Granada, Spain

[21] Hosp Univ Marques Valdecilla, Santander, Spain

[22] Ctr Hosp Lyon Sud, Lyon, France

[23] Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[24] Hosp Clin Barcelona, Inst Canc & Blood Dis, Hematopoiet Stem Cell Transplantat Unit, Barcelona, Spain

[25] Chaim Sheba Med Ctr, Hematol Div, Tel Hashomer, Ramat Gan, Israel

[26] Univ Barcelona, Hosp Duran & Reynals, Inst Catala Oncol, Inst Invest Biomed Bellvitge,Hemotol Dept, Barcelona, Spain

[27] Asklepios Klin St Georg, Dept Hematol, Oncol & Stem Cell Transplantat, Hamburg, Germany

来源：

TRANSPLANTATION AND CELLULAR THERAPY | 2024年 / 30卷 / 02期

关键词：

Post-transplant; cyclophosphamide; allogeneic hematopoietic; stem cell transplantation; Hodgkin lymphoma; STEM-CELL TRANSPLANTATION; REDUCED-INTENSITY; SIBLING TRANSPLANT; HOST-DISEASE; OUTCOMES; AML; LEUKEMIA; REGISTRY; RELAPSE;

D O I：

10.1016/j.jtct.2023.11.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Post -transplantation cyclophosphamide (PTCy) has emerged as a promising approach for preventing graft -versus -host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, there is a lack of studies examining the impact of this GVHD prophylaxis when different donor types are used in patients with Hodgkin lymphoma (HL). This study compared the outcomes of patients with HL undergoing HSCT from HLA-matched donors, including matched sibling donors (MSDs) and matched unrelated donors (MUDs), and haploidentical donors, using PTCy as the GVHD prophylaxis approach in all cohorts. We retrospectively compared outcomes of allo-HSCT from 166 HLA-matched donors (96 sibling and 70 unrelated donors) and 694 haploidentical donors using PTCybased GVHD prophylaxis in patients with HL registered in the European Society for Blood and Marrow Transplantation database from 2010 to 2020. Compared to HLA-matched HSCT, haploidentical donor HSCT was associated with a significantly lower rate of platelet engraftment (86% versus 94%; P < .001) and a higher rate of grade II -IV acute GVHD (34% versus 24%; P = .01). The 2 -year cumulative incidence of nonrelapse mortality (NRM) was significantly lower in the HLA-matched cohort compared to the haploidentical cohort (10% versus 18%; P = .02), resulting in a higher overall survival (OS) rate (82% versus 70%; P = .002). There were no significant differences between the 2 cohorts in terms of relapse, progression -free survival, or GVHD-free relapse -free survival. In multivariable analysis, haploidentical HSCT was associated with an increased risk of grade II -IV acute GVHD and NRM and worse OS compared to HLA-matched HSCT. Our findings suggest that in the context of PTCy-based GVHD prophylaxis, transplantation from HLA-matched donors appears to be a more favorable option compared to haploidentical HSCT. (c) 2023 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

引用

页码：210.e1 / 210.e14

页数：14

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