Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

被引：22

作者：

Cotino-Najera, Sandra ^{[1
]}

Herrera, Luis A. ^{[1
,2
]}

Dominguez-Gomez, Guadalupe ^{[3
]}

Diaz-Chavez, Jose ^{[4
]}

机构：

[1] Ctr Invest & Estudios Avanzados Inst Politecn Nacl, Dept Genet & Biol Mol, Lab Oncol Mol, Mexico City, Mexico

[2] Tecnol Monterrey, Escuela Med & Ciencias Salud Tecnol Monterrey, Mexico City, Mexico

[3] Inst Nacl Cancerol INCAN, Subdirecc Invest Clin, Mexico City, Mexico

[4] Univ Nacl Autonoma Mexico, Unidad Invest Cancerol, Inst Invest Biomed, Mexico City, Mexico

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

radioresistance; chemoresistance; resveratrol; cancer; molecular mechanisms; NF-KAPPA-B; HYPOXIA-INDUCED CHEMORESISTANCE; SQUAMOUS-CELL CARCINOMAS; FACTOR RECEPTOR BLOCKADE; NONCODING RNA MALAT1; PROSTATE-CANCER; DRUG-RESISTANCE; COLORECTAL-CANCER; IONIZING-RADIATION; P-GLYCOPROTEIN;

D O I：

10.3389/fphar.2023.1287505

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer. A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment.

引用

页数：24

共 330 条

[71] Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma [J].

Fanelli, Marilu ;

Hattinger, Claudia Maria ;

Vella, Serena ;

Tavanti, Elisa ;

Michelacci, Francesca ;

Gudeman, Beth ;

Barnett, Daryl ;

Picci, Piero ;

Serra, Massimo .

CURRENT CANCER DRUG TARGETS, 2016, 16 (03) :261-274

[72] A potential role for resveratrol as a radiation sensitizer for melanoma treatment [J].

Fang, Yujiang ;

Bradley, Moore J. ;

Cook, Kathryn M. ;

Herrick, Elizabeth J. ;

Nicholl, Michael B. .

JOURNAL OF SURGICAL RESEARCH, 2013, 183 (02) :645-653

[73] Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis [J].

Fang, Yujiang ;

DeMarco, Vincent G. ;

Nicholl, Michael B. .

CANCER SCIENCE, 2012, 103 (06) :1090-1098

[74]

Fenig E, 2004, ONCOL REP, V11, P213

[75] Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues [J].

Ferraz da Costa, Danielly C. ;

Rangel, Luciana Pereira ;

Duarte da Cunha Martins-Dinis, Mafalda Maria ;

da Silva Ferretti, Giulia Diniz ;

Ferreira, Vitor F. ;

Silva, Jerson L. .

MOLECULES, 2020, 25 (04)

[76] Transient Transfection of a Wild-Type p53 Gene Triggers Resveratrol-Induced Apoptosis in Cancer Cells [J].

Ferraz da Costa, Danielly Cristiny ;

Casanova, Fabiana Alves ;

Quarti, Julia ;

Malheiros, Maite Santos ;

Sanches, Daniel ;

dos Santos, Patricia Souza ;

Fialho, Eliane ;

Silva, Jerson L. .

PLOS ONE, 2012, 7 (11)

[77]

Fink Marc Y, 2013, Genes Cancer, V4, P187, DOI 10.1177/1947601913488598

[78]

Flynn V, 2003, INT J ONCOL, V23, P317

[79] Mechanism of Cell Adaptation When and How Do Cancer Cells Develop Chemoresistance? [J].

Fodale, Valentina ;

Pierobon, Mariaelena ;

Liotta, Lance ;

Petricoin, Emanuel .

CANCER JOURNAL, 2011, 17 (02) :89-95

[80] Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].

Fontenot, Jason D. ;

Gavin, Marc A. ;

Rudensky, Alexander Y. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992

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