Myosin heavy-chain myopathy in 2 American quarter horses

被引：2
作者：
Faccin, Mayane [1 ]
Landsgaard, Kirsten A. [1 ]
Milliron, Sarai M. [1 ]
Jennings, Alexis H. [1 ]
Keith Chaffin, M. [1 ]
Giaretta, Paula R. [1 ]
Rech, Raquel R. [1 ,2 ]
机构：
[1] Texas A&M Univ, College Stn, TX USA
[2] Texas A&M Univ, Sch Vet Med & Biomed Sci, Dept Vet Pathobiol, 4467 TAMU, College Stn, TX 77845 USA
来源：
VETERINARY PATHOLOGY | 2024年 / 61卷 / 03期
关键词：
horse; immune-mediated myositis; myosin heavy chain 1; myosin heavy-chain myopathy; MYH1; Streptococcus equi subsp. equi; Actinobacillus equuli; IMMUNE-MEDIATED MYOSITIS; MUSCLE;
D O I：
10.1177/03009858231204253
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 1.5-year-old American quarter horse gelding (case 1) and an 11-month-old American quarter horse filly (case 2) were presented for acute onset pelvic lameness and lethargy. Case 1 had nasal discharge, while case 2 developed rapid muscle atrophy. Both horses had elevated serum creatine kinase activity. The horses showed similar polyphasic histiocytic and lymphoplasmacytic myositis with necrosis, mineralization, and regeneration. Additionally, case 1 had Streptococcus equi subsp. equi-induced suppurative retropharyngeal lymphadenitis with renal purpura hemorrhagica and myoglobinuric nephropathy. A focal pulmonary abscess caused by Actinobacillus equuli was found in case 2. Genetic testing revealed case 1 as heterozygous and case 2 as homozygous for the E321G MYH1 variant, supporting the diagnosis of myosin heavy-chain myopathy, with concomitant bacterial disease as potential triggers.
引用
收藏
页码：462 / 467
页数：6
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