Study design and methods: US study to protect brain health through lifestyle intervention to reduce risk (US POINTER)

被引：32

作者：

Baker, Laura D. ^{[1
,2
,3
]}

Snyder, HeatherM. ^{[4
]}

Espeland, Mark A. ^{[1
,2
]}

Whitmer, Rachel A. ^{[5
]}

Kivipelto, Miia ^{[6
,7
,8
,9
]}

Woolard, Nancy ^{[1
]}

Katula, Jeffrey

Papp, Kathryn V. ^{[11
,12
,13
]}

Ventrelle, Jennifer ^{[10
,14
]}

Graef, Sarah ^{[14
]}

Hill, Marcus A. ^{[1
]}

Rushing, Scott ^{[2
]}

Spell, Julia ^{[2
]}

Lovato, Laura ^{[2
]}

Felton, Deborah ^{[2
]}

Williams, Benjamin J. ^{[3
]}

Nouran, Mina Ghadimi

Raman, Rema ^{[15
]}

Ngandu, Tiia ^{[6
,16
]}

Solomon, Alina ^{[6
,8
,9
,17
]}

Wilmoth, Sharon ^{[1
]}

Cleveland, Maryjo L. ^{[1
]}

Williamson, Jeff D. ^{[1
]}

Lambert, Katherine L. ^{[18
]}

Farias, Sarah Tomaszewski ^{[19
]}

Day, Claire E. ^{[20
]}

Tangney, Christy C. ^{[15
]}

Gitelman, Darren R. ^{[21
]}

Matongo, Olivia ^{[22
]}

Reynolds, Terrianne ^{[22
]}

Pavlik, Valory N. ^{[23
]}

Yu, Melissa M. ^{[23
]}

Alexander, Ashley S. ^{[24
]}

Elbein, Richard ^{[25
]}

McDonald, Ann Marie ^{[25
]}

Salloway, Stephen ^{[26
,27
]}

Wing, Rena R. ^{[28
]}

Antkowiak, Susan ^{[29
]}

Morris, Martha Clare ^{[14
]}

Carrillo, Maria C. ^{[4
]}

机构：

[1] Wake Forest Univ, Dept Internal Med, Sch Med, Winston Salem, NC USA

[2] Wake Forest Univ, Div Publ Hlth Sci, Sch Med, Winston Salem, NC USA

[3] Wake Forest Univ, Dept Neurol, Sch Med, Winston Salem, NC USA

[4] Alzheimers Assoc, Chicago, IL USA

[5] Univ Calif Davis, Dept Publ Hlth Sci, Sacramento, CA USA

[6] Karolinska Inst, Div Clin Geriat, Ctr Alzheimer Res, Stockholm, Sweden

[7] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[8] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England

[9] FINGERS Brain Hlth Inst, Stockholm, Sweden

[10] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC USA

[11] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[12] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[13] Harvard Med Sch, Dept Neurol, Boston, MA USA

[14] Rush Univ, Dept Clin Nutr & Family & Prevent Med, Med Ctr, Chicago, IL USA

[15] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA

[16] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

[17] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

[18] Western Carolina Chapter, Alzheimers Assoc, Charlotte, NC USA

[19] Univ Calif Davis, Dept Neurol, Sacramento, CA USA

[20] Northern Calif Northern Nevada Chapter, Alzheimers Assoc, San Jose, CA USA

[21] Advocate Hlth Care, Dept Behav Neurol, Downers Grove, IL USA

[22] Illinois Chapter, Alzheimers Assoc, Chicago, IL USA

[23] Baylor Coll Med, Dept Neurol, Houston, TX USA

[24] Kelsey Res Fdn, Houston, TX USA

[25] Houston & Southeast Texas Chapter, Alzheimers Assoc, Houston, TX USA

[26] Brown Univ, Butler Hosp, Memory & Aging Program, Providence, RI USA

[27] Brown Univ, Warren Alpert Med Sch, Providence, RI USA

[28] Brown Univ, Sch Med, Dept Psychiat & Human Behav, Providence, RI USA

[29] Rhode Isl Chapter, Alzheimers Assoc, Providence, RI USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 02期

关键词：

aging; Alzheimer's disease; clinical trial; cognition; cognitive training; diet; exercise; lifestyle; intervention; non-pharmacological; prevention; risk modification; MILD COGNITIVE IMPAIRMENT; OLDER-ADULTS; TELEPHONE INTERVIEW; AEROBIC EXERCISE; DIET; PREVENTION; PROMOTION; DEMENTIA; DISEASE;

D O I：

10.1002/alz.13365

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans. METHODS: U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to wellestablished factors. The primary outcome is a global cognition composite that permits harmonization with FINGER. RESULTS: U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing. DISCUSSION: U.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies.

引用

页码：769 / 782

页数：14

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