The Impact of Human Platelet Antigen Allele on Antiplatelet Antibodies and Cryoglobulins in Patients with Primary Immune Thrombocytopenia and Hepatitis C Virus-Associated Immune Thrombocytopenia

被引：0

作者：

Huang, Cih-En ^{[1
,6
,7
]}

Chen, Yi-Yang ^{[1
]}

Chang, Jung -Jung ^{[2
]}

Wu, Yu-Ying ^{[1
]}

Chen, Wei -Ming ^{[3
]}

Wang, Ying-Hsuan ^{[1
]}

Chen, Min-Chi ^{[4
,8
,9
]}

Lu, Chang-Hsien ^{[1
]}

Shi, Chung-Sheng ^{[5
,6
]}

Chen, Chih-Cheng ^{[1
,7
,10
]}

机构：

[1] Chang Gung Mem Hosp, Dept Med, Div Hematol & Oncol, Chiayi, Taiwan

[2] Chang Gung Mem Hosp, Dept Med, Div Cardiol, Chiayi, Taiwan

[3] Chang Gung Mem Hosp, Dept Med, Div Gastroenterol & Hepatol, Chiayi, Taiwan

[4] Chang Gung Mem Hosp, Dept Obstet & Gynecol, Chiayi, Taiwan

[5] Chang Gung Mem Hosp, Dept Surg, Div Urol, Chiayi, Taiwan

[6] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Taoyuan, Taiwan

[7] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[8] Chang Gung Univ, Coll Med, Dept Publ Hlth, Taoyuan, Taiwan

[9] Chang Gung Univ, Coll Med, Biostat Consulting Ctr, Taoyuan, Taiwan

[10] 8 Sec West, Chia Pu Rd, Pu Tz City, Chiayi, Taiwan

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2023年 / 15卷 / 01期

关键词：

Antiplatelet antibody; Cryoglobulinemia; Hepatitis C virus; Human platelet antigen; Immune thrombocytopenia; ALLOANTIBODIES; FREQUENCIES; PURPURA; RISK;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background And Objectives: Human platelet antigens (HPAs) are alloantigens associated with antiplatelet alloantibodies and the risk of immune thrombocytopenia (ITP). However, few studies have investigated associations among HPAs, antiplatelet autoantibodies, and cryoglobulins.Methods: We enrolled 43 patients with primary ITP, 47 with hepatitis C virus-associated ITP (HCV-ITP), 21 with hepatitis B virus-associated ITP (HBV-ITP), 25 controls with HCV, and 1013 normal controls. We analyzed HPA allele frequencies, including HPA1-6 and 15, antiplatelet antibodies binding to platelet glycoprotein (GP) IIb/IIIa, Ia/IIa, Ib/IX, IV, human leukocyte antigen class I, cryoglobulin IgG/A/M, and their associations with thrombocytopenia.Results: In the ITP cohort, HPA2ab, rather than HPA2aa, predicted a low platelet count. HPA2b was associated with the risk of developing ITP. HPA15b was correlated with multiple antiplatelet antibodies. In HCV-ITP patients, HPA3b was correlated with anti-GPIIb/IIIa antibodies. HCV-ITP patients with anti-GPIIb/IIIa antibodies had a higher positive rate of cryoglobulin IgG and IgA compared with those without anti-GPIIb/IIIa antibodies. Overlapping detection was also found among other antiplatelet antibodies and cryoglobulins. Like the antiplatelet antibodies, cryoglobulins were associated with clinical thrombocytopenia, implying their close relationship. Finally, we extracted cryoglobulins to confirm the exhibition of cryoglobulin-like antiplatelet antibodies. In contrast, in primary ITP patients, HPA3b was correlated with cryoglobulin IgG/A/M rather than anti-GPIIb/IIIa antibodies.Conclusion: HPA alleles were associated with antiplatelet autoantibodies and had different impacts in primary ITP and HCV-ITP patients. HCV-ITP was considered to be a symptom of mixed cryoglobulinemia in HCV patients. The pathophysiology may differ between these two groups.

引用

页数：10