Anti-CLL1-based CAR T-cells with 4-1-BB or CD28/CD27 stimulatory domains in treating childhood refractory/relapsed acute myeloid leukemia

被引：18

作者：

Pei, Kunlin ^{[1
,2
]}

Xu, Haoyu ^{[1
,2
]}

Wang, Pengfei ^{[1
]}

Gan, Wening ^{[1
]}

Hu, Zhengbin ^{[1
]}

Su, Xiaoling ^{[1
]}

Zhang, Hui ^{[1
]}

He, Yingyi ^{[1
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Hematol Oncol, 9 Jinsui Rd, Guangzhou 510623, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Guangzhou 511495, Guangdong, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 08期

基金：

中国国家自然科学基金;

关键词：

4-1-BB; acute myeloid leukemia; anti-CLL1 CAR T cells; CD28; CD27; refractory; relapsed;

D O I：

10.1002/cam4.5916

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThough the efficacy of anti C-type lectin-like molecule-1 (CLL1) CAR T-cells in refractory/relapsed acute myeloid leukemia (R/R-AML) have been occasionally reported, the influence of co-stimulatory domain CAR T-cells is not investigated so far. MethodSeven R/R-AML children treated with anti-CLL1 CAR T-cells were enrolled onto this preliminary comparison study. Among these seven patients, four received CD28/CD27-based CAR T-cells therapy, and three received 4-1BB-based CAR T-cells therapy. ResultThe overall response rates were 75% and 66.7% in CD28/CD27 and 4-1BB group respectively. All patients experienced grade 1 to 2 cytokine release syndrome, with only one patient experiencing grade 2 immune effector cell-associated neurotoxicity syndrome. The maximum CAR T-cells durations were 156 and 274 days for CD28/CD27 group and 4-1BB group respectively. The 1-yr overall survival rate was 57.1%. ConclusionsA preliminary similar efficacy/safety index was observed in anti-CLL1-based CAR T-cells with 4-1BB or CD28/CD27 co-stimulatory elements in treating pediatric R/R-AML.

引用

页码：9655 / 9661

页数：7

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