The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases

被引：7

作者：

Sharif, Arazu ^{[1
,5
]}

Mamo, John ^{[1
,2
]}

Lam, Virginie ^{[1
,3
]}

Al-Salami, Hani ^{[1
,5
]}

Mooranian, Armin ^{[1
,5
]}

Watts, Gerald F. ^{[4
]}

Clarnette, Roger ^{[4
]}

Luna, Giuseppe ^{[5
]}

Takechi, Ryu ^{[1
,3
]}

机构：

[1] Curtin Univ, Fac Hlth Sci, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

[2] Perron Inst Neurol & Translat Res, Perth, WA, Australia

[3] Curtin Univ, Fac Hlth Sci, Sch Publ Hlth, Perth, WA, Australia

[4] Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia

[5] Curtin Univ, Fac Hlth Sci, Curtin Med Sch, Perth, WA, Australia

来源：

TRANSLATIONAL NEURODEGENERATION | 2024年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

Neurodegenerative disease; Probucol; Probucol analogues; Inflammation; Blood-brain barrier; Oxidative stress; Amyloid-beta; BLOOD-BRAIN-BARRIER; AMYLOID-BETA PEPTIDE; CHOLESTEROL-LOWERING DRUG; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; SIGNALING PATHWAY; IN-VITRO; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDANT BO-653;

D O I：

10.1186/s40035-024-00398-w

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood-brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies. Emerging research indicates that probucol, a historic lipid-lowering medication, offers substantial potential in the realm of neurodegenerative disease prevention and treatment. Preclinical investigations have unveiled multifaceted cellular effects of probucol, showcasing its remarkable antioxidative and anti-inflammatory properties, its ability to fortify the BBB and its direct influence on neural preservation and adaptability. These diverse effects collectively translate into enhancements in both motor and cognitive functions. This review provides a comprehensive overview of recent findings highlighting the efficacy of probucol and probucol-related compounds in the context of various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and cognitive impairment associated with diabetes.

引用

页数：12

共 126 条

[31] H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway [J].