A mechanistic blueprint for enzymatic reduction by a modular polyketide synthase

被引:0
作者
Fraley, Amy E. [1 ]
机构
[1] Eidgenoss TH ETH Zurich, Inst Microbiol, Zurich, Switzerland
关键词
D O I
10.1016/j.str.2023.08.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this issue of Structure, McCullough et al. describe linker peptides that serve as a "hydrophobic glue"to arrange the domains within the reducing region of a modular polyketide synthase. Comparisons to structural data from other megasynthases identified features that are unique to modular systems.
引用
收藏
页码:1013 / 1015
页数:3
相关论文
共 50 条
[41]   Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation [J].
Fraley, Amy E. ;
Dell, Maria ;
Schmalhofer, Maximilian ;
Meoded, Roy A. ;
Bergande, Cedric ;
Groll, Michael ;
Piel, Jorn .
STRUCTURE, 2023, 31 (05) :565-+
[42]   Modular polyketide synthase contains two reaction chambers that operate asynchronously [J].
Bagde, Saket R. ;
Mathews, Irimpan I. ;
Fromme, J. Christopher ;
Kim, Chu-Young .
SCIENCE, 2021, 374 (6568) :723-+
[43]   ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE [J].
KAO, CM ;
LUO, GL ;
KATZ, L ;
CANE, DE ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (25) :11612-11613
[44]   ClusterCAD: a computational platform for type I modular polyketide synthase design [J].
Eng, Clara H. ;
Backman, Tyler W. H. ;
Bailey, Constance B. ;
Magnan, Christophe ;
Martin, Hector Garcia ;
Katz, Leonard ;
Baldi, Pierre ;
Keasling, Jay D. .
NUCLEIC ACIDS RESEARCH, 2018, 46 (D1) :D509-D515
[45]   REPOSITIONING OF A DOMAIN IN A MODULAR POLYKETIDE SYNTHASE TO PROMOTE SPECIFIC CHAIN CLEAVAGE [J].
CORTES, J ;
WIESMANN, KEH ;
ROBERTS, GA ;
BROWN, MJB ;
STAUNTON, J ;
LEADLAY, PF .
SCIENCE, 1995, 268 (5216) :1487-1489
[46]   MANIPULATION OF MACROLIDE RING SIZE BY DIRECTED MUTAGENESIS OF A MODULAR POLYKETIDE SYNTHASE [J].
KAO, CM ;
LUO, GL ;
KATZ, L ;
CANE, DE ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (35) :9105-9106
[47]   An Unusual Extender Unit Is Incorporated into the Modular Polyketide Synthase of Scopranones Biosynthesis [J].
Demachi, Ayumu ;
Uchida, Ryuji ;
Arima, Shiho ;
Nagamitsu, Tohru ;
Hashimoto, Junko ;
Komatsu, Mamoru ;
Kozone, Ikuko ;
Shin-ya, Kazuo ;
Tomoda, Hiroshi ;
Ikeda, Haruo .
BIOCHEMISTRY, 2019, 58 (50) :5066-5073
[48]   Enzymatic formation of unnatural novel polyketide scaffolds by plant-specific type III polyketide synthase [J].
Shi, She-Po ;
Morita, Hiroyuki ;
Wanibuchi, Kiyofumi ;
Noguchi, Hiroshi ;
Abe, Ikuro .
TETRAHEDRON LETTERS, 2009, 50 (18) :2150-2153
[49]   Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase [J].
Abe, Ikuro ;
Abe, Tsuyoshi ;
Wanibuchi, Kiyofumi ;
Noguchi, Hiroshi .
ORGANIC LETTERS, 2006, 8 (26) :6063-6065
[50]   Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase [J].
Englund, Elias ;
Schmidt, Matthias ;
Nava, Alberto A. ;
Lechner, Anna ;
Deng, Kai ;
Jocic, Renee ;
Lin, Yingxin ;
Roberts, Jacob ;
Benites, Veronica T. ;
Kakumanu, Ramu ;
Gin, Jennifer W. ;
Chen, Yan ;
Liu, Yuzhong ;
Petzold, Christopher J. ;
Baidoo, Edward E. K. ;
Northen, Trent R. ;
Adams, Paul D. ;
Katz, Leonard ;
Yuzawa, Satoshi ;
Keasling, Jay D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (16) :8822-8832