Association of a Genetic Variant in Chromosome 9p21 with Increased Risk of Developing Cervical Cancer

被引：5

作者：

Atabati, Mojde ^{[1
,2
]}

Saber, Razieh ^{[1
]}

Malakuti, Parnian ^{[3
]}

Pourali, Ghazaleh ^{[4
,5
]}

Heydari-Majd, Motahareh ^{[2
]}

Safavi, Pegah ^{[6
]}

Dashti, Mohammad ^{[4
]}

Moghadam, Azam Rastgar ^{[5
]}

Rahmani, Farzad ^{[4
,5
,7
]}

Farazestanian, Marjaneh ^{[1
]}

Behboodi, Negin ^{[1
]}

Mehramiz, Mehrane ^{[5
]}

Nassiri, Mohammadreza ^{[8
]}

Rajabian-Noghondar, Majid ^{[2
]}

Rahbarian, Raheleh ^{[2
]}

Ramshini, Hassan ^{[2
]}

Jafarian, Amirhosein ^{[9
]}

Ferns, Gordon ^{[10
]}

Avan, Amir ^{[4
,5
,11
]}

Hasanzadeh, Malihe ^{[1
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Woman Hlth Res Ctr, Dept Gynecol Oncol, Mashhad, Iran

[2] Payame Noor Univ, Fac Sci, Dept Biol, POB 19395-3697, Tehran, Iran

[3] Szeged Univ Med Sci, Fac Med, Dept Med Biol, Szeged, Hungary

[4] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Basic Med Sci Inst, Mashhad, Iran

[6] Islamic Azad Univ, Dept Med Radiat, Sci & Res Branch, Tehran, Iran

[7] Mashhad Univ Med Sci, Kashmar Sch Nursing, Mashhad, Iran

[8] Ferdowsi Univ Mashhad, Res Inst Biotechnol, Recombinant Prot Res Grp, Mashhad, Iran

[9] Mashhad Univ Med Sci, Fac Med, Dept Pathol, Mashhad, Iran

[10] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

[11] Mashhad Univ Med Sci, Med Genet Res Ctr, Mashhad, Iran

来源：

CURRENT CANCER THERAPY REVIEWS | 2023年 / 19卷 / 04期

关键词：

Cervical cancer; rs1333049; 9p21; genetic variant; gynecologic cancers; human malignancies; LONG NONCODING RNA; POOR-PROGNOSIS; ANRIL; POLYMORPHISMS; REGION;

D O I：

10.2174/1573394719666230321153528

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Cervical cancer is one of the most prevalent gynecologic cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in chromosome 9p21 and the risk of cervical carcinogenesis.Methods: The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method.Results: The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia using recessive and additive genetic models (p < 0.001).Conclusion: Our findings indicated that the CDKN2A/B genetic variant (rs1333049) was significantly associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical carcinogenesis.

引用

页码：358 / 362

页数：5

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