Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy

被引:0
作者
Sakaeda, Yukinori [1 ]
Kato, Aki [1 ]
Kuwayama, Soichiro [1 ]
Hirahara, Shuichiro [1 ]
Suzuki, Norihiro [1 ]
Ogura, Yuichiro [1 ]
Nakazawa, Yoko [2 ]
Yasukawa, Tsutomu [1 ]
机构
[1] Nagoya City Univ, Grad Sch Med Sci, Dept Ophthalmol & Visual Sci, 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan
[2] Nagoya City Univ, West Med Ctr, Dept Ophthalmol, 1-1-1 Hirate Cho,Kita Ku, Nagoya 4628508, Japan
关键词
age-related macular degeneration; anti-vascular endothelial growth factor therapy; photodynamic therapy; polypoidal choroidal vasculopathy; MACULAR DEGENERATION; TRIAMCINOLONE ACETONIDE; INTRAVITREAL RANIBIZUMAB; JAPANESE PATIENTS; NEOVASCULARIZATION; VERTEPORFIN; BEVACIZUMAB; GUIDELINES; INJECTION; EFFICACY;
D O I
10.3390/jcm12144707
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We evaluated the long-term prognosis of the eyes of patients with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT). In total, 60 eyes of 57 patients diagnosed with PCV and treated with PDT were reviewed retrospectively in real-world settings. The best-corrected visual acuity (BCVA), central retinal thickness (CRT), anatomical findings (vision-threatening findings), and treatment history were assessed. In total, 38 eyes underwent PDT as the initial treatment (initial PDT group) and 22 eyes underwent PDT as a rescue treatment (rescue PDT group). In the initial PDT group, 11 eyes (29%) did not require additional therapy throughout the observation period and maintained good BCVA. A total of 27 eyes (71%) underwent additional treatments and the mean BCVA was only stabilized for 2 years; thereafter, decreased vision occurred even with additional treatments. In the rescue PDT group, 22 eyes (95%) required additional treatment. Hard exudate, serous pigment epithelial detachment, and the total vision-threatening score were related to worse BCVA. Initial PDT may be effective in about 30% of cases with preservation of good vision and no need for additional treatment. However, patients with received rescue PDT needed additional treatment in most cases and the vision decreased in many cases.
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页数:14
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