Cytokine/chemokine levels in the CSF and serum of anti-NMDAR encephalitis: A systematic review and meta-analysis

被引:11
作者
Ma, Yushan [1 ,2 ]
Wang, Jierui [3 ]
Guo, Shuo [1 ]
Meng, Zirui [1 ]
Ren, Yan [1 ]
Xie, Yi [1 ]
Wang, Minjin [1 ,3 ]
机构
[1] Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Peoples R China
[2] Third Hosp Mianyang, Sichuan Mental Hlth Ctr, Dept Lab Med, Mianyang, Peoples R China
[3] Sichuan Univ, Dept Neurol, West China Hosp, Chengdu, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷
关键词
cytokine; chemokine; T cell; NMDAR encephalitis; meta-analysis; ASPARTATE RECEPTOR ENCEPHALITIS; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; APRIL LEVELS; DIAGNOSIS; CYTOKINE; BRAIN; BIOMARKER; DISEASE; CXCL13;
D O I
10.3389/fimmu.2022.1064007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives To summarize the cytokine/chemokine levels of anti-N-methyl-Daspartate receptor encephalitis (NMDAR-E) and explore the potential role of these molecules and immune cells in the pathogenic mechanism.Methods The PubMed, Cochrane Library, Embase, and Web of Science databases were searched for various articles that assessed the concentrations of cytokines/chemokines in the unstimulated cerebrospinal fluid (CSF) or serum of patients with NMDAR-E in this systematic review and meta-analysis. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated by Stata17.0.Results A total of 19 articles were included in the systematic review from 260 candidate papers, and cytokine/chemokine levels reported in the CSF/serum were examined in each article. This meta-analysis included 17 eligible studies comprising 579 patients with NMDAR-E, 367 patients with noninflammatory neurological disorders, and 42 healthy controls from China, Spain, South Korea, Australia, Czechia, and Sweden. The results indicated that the levels of different cytokines interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, IL-10, IL-13, IL-1 beta, IL-12, and IL-17 and chemokine C-X-C motif ligand (CXCL)10 in the CSF were significantly higher in NMDAR-E patients with a large effect size. In addition, B cell activating factor (BAFF), CXCL13, and interferon (IFN)-gamma levels in the CSF were higher in NMDAR-E patients with a middle effect size. In contrast, levels of IL-2 and IL-4 in the CSF and CXCL13 and BAFF in the serum did not show a significant difference between cases and controls.Conclusions These analyses showed that the central immune response in NMDAR-E is a process that involves multiple immune cell interactions mediated by cytokines/chemokines, and T cells play an important role in the pathogenesis of immunity.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022342485).
引用
收藏
页数:10
相关论文
共 78 条
  • [1] The HMGB1 is increased in CSF of patients with an Anti-NMDAR encephalitis
    Ai, P.
    Zhang, X.
    Xie, Z.
    Liu, G.
    Liu, X.
    Pan, S.
    Wang, H.
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 2018, 137 (02): : 277 - 282
  • [2] Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis
    Al-Diwani, Adam
    Theorell, Jakob
    Damato, Valentina
    Bull, Joshua
    McGlashan, Nicholas
    Green, Edward
    Kienzler, Anne-Kathrin
    Harrison, Ruby
    Hassanali, Tasneem
    Campo, Leticia
    Browne, Molly
    Easton, Alistair
    Majd, Hooman Soleymani
    Tenaka, Keiko
    Iorio, Raffaele
    Dale, Russell C.
    Harrison, Paul
    Geddes, John
    Quested, Digby
    Sharp, David
    Lee, Soon-Tae
    Nauen, David W.
    Makuch, Mateusz
    Lennox, Belinda
    Fowler, Darren
    Sheerin, Fintan
    Waters, Patrick
    Leite, M. Isabel
    Handel, Adam E.
    Irani, Sarosh R.
    [J]. BRAIN, 2022, 145 (08) : 2742 - 2754
  • [3] The clinical relevance of serum versus CSF NMDAR autoantibodies associated exclusively with psychiatric features: a systematic review and meta-analysis of individual patient data
    Blackman, Graham
    Lim, Mao Fong
    Pollak, Thomas
    Al-Diwani, Adam
    Symmonds, Mkael
    Mazumder, Asif
    Carter, Ben
    Irani, Sarosh
    David, Anthony
    [J]. JOURNAL OF NEUROLOGY, 2022, 269 (10) : 5302 - 5311
  • [4] Pediatric autoimmune encephalitis in Denmark during 2011-17: A nationwide multicenter population-based cohort study
    Boesen, Magnus Spangsberg
    Born, Alfred Peter
    Lydolph, Magnus Christian
    Blaabjerg, Morten
    Borresen, Malene Landbo
    [J]. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2019, 23 (04) : 639 - 652
  • [5] Borish Larry C., 2003, Journal of Allergy and Clinical Immunology, V111, pS460
  • [6] Microglia: Immune and non-immune functions
    Borst, Katharina
    Dumas, Anaelle Aurelie
    Prinz, Marco
    [J]. IMMUNITY, 2021, 54 (10) : 2194 - 2208
  • [7] Distinct intrathecal interleukin-17/interleukin-6 activation in anti-N-methyl-D-aspartate receptor encephalitis
    Byun, Jung-Ick
    Lee, Soon-Tae
    Moon, Jangsup
    Jung, Keun-Hwa
    Sunwoo, Jun-Sang
    Lim, Jung-Ah
    Kim, Tae-Joon
    Shin, Yong-Won
    Lee, Keon-Joo
    Jun, Jin-Sun
    Lee, Han Sang
    Lee, Woo-Jin
    Kim, Young-Sook
    Kim, Soyun
    Jeon, Daejong
    Park, Kyung-Il
    Jung, Ki-Young
    Kim, Manho
    Chu, Kon
    Lee, Sang Kun
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2016, 297 : 141 - 147
  • [8] Increased Levels of Proinflammatory Cytokines in the Aged Rat Brain Attenuate Injury-induced Cytokine Response After Excitotoxic Damage
    Campuzano, O.
    Castillo-Ruiz, M. M.
    Acarin, L.
    Castellano, B.
    Gonzalez, B.
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2009, 87 (11) : 2484 - 2498
  • [9] Elevation of YKL-40 in the CSF of Anti-NMDAR Encephalitis Patients Is Associated With Poor Prognosis
    Chen, Jinyu
    Ding, Yuewen
    Zheng, Dong
    Wang, Zhanhang
    Pan, Suyue
    Ji, Teng
    Shen, Hai-Ying
    Wang, Honghao
    [J]. FRONTIERS IN NEUROLOGY, 2018, 9
  • [10] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Dalmau, Josep
    Tuzun, Erdem
    Wu, Hai-yan
    Masjuan, Jaime
    Rossi, Jeffrey E.
    Voloschin, Alfredo
    Baehring, Joachim M.
    Shimazaki, Haruo
    Koide, Rej
    King, Dale
    Mason, Warren
    Sansing, Lauren H.
    Dichter, Marc A.
    Rosenfeld, Myrna R.
    Lynch, David R.
    [J]. ANNALS OF NEUROLOGY, 2007, 61 (01) : 25 - 36