Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women

被引：1
作者：
Bastos, Clarissa Ribeiro [1 ,2 ]
Bock, Bertha Bueno [1 ]
Xavier, Janaina [1 ]
Camerini, Laisa [1 ]
Dewes, Samantha Seibt [1 ]
Grellert, Mateus [2 ]
de Carvalho, Hudson Wander [3 ]
Jansen, Karen [1 ]
da Silva, Ricardo Azevedo [1 ]
Pinheiro, Ricardo Tavares [1 ]
de Mattos Souza, Luciano [1 ]
Oses, Jean Pierre [4 ]
Portela, Luis Valmor [5 ]
Lara, Diogo Rizzato [6 ]
Tovo-Rodrigues, Luciana [7 ]
Ghisleni, Gabriele [1 ]
机构：
[1] Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Ctr Hlth Sci, 373,324C Goncalves Chaves St, BR-96015560 Pelotas, RS, Brazil
[2] Univ Fed Santa Catarina, Florianopolis, SC, Brazil
[3] Univ Fed Pelotas, Dept Psychol, Pelotas, RS, Brazil
[4] Fed Univ Rio Grande, Inst Biol Sci, Rio Grande, RS, Brazil
[5] Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, RS, Brazil
[6] Pontifical Catholica Univ Rio Grande, Dept Cellular & Mol Biol, Porto Alegre, RS, Brazil
[7] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil
来源：
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2023年 / 273卷 / 01期
关键词：
Calcium channels L-type; Bipolar disorder; Temperament; AFECTS; Sex differences; PERSONALITY-TRAITS; ASSOCIATION ANALYSIS; GENETIC-VARIATION; I DISORDER; SEX; SYMPTOMS; BEHAVIOR; VARIANT; IMPACT; SCALE;
D O I：
10.1007/s00406-022-01493-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits on the relationship between two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) and BD according to sex. This is a cross-sectional study consisting of 878 Caucasian individuals (508 women and 370 men), aged 18-35, enrolled in a population-based study in the city of Pelotas, Southern Brazil. BD diagnosis was evaluated using the clinical interview MINI 5.0, and temperament traits were assessed via the application of the Affective and Emotional Composite Temperament Scale (AFECTS). Mediation models were tested using the modeling tool PROCESS (version 3.3) for SPSS. Bootstrapping-enhanced mediation analyses in women indicated that traits anger (39%) and caution (27%) mediated the association between the rs4765913 SNP and BD, while traits volition (29%), anger (35%), and caution (29%) mediated the association between the AA haplotype (rs1006737-rs4765913) and the BD. No effect was encountered for cisgender men. Our model revealed that paths from CACNA1C SNPs to BD are mediated by specific temperament traits in women, reinforcing the definition of temperament traits as endophenotypes.
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页码：41 / 50
页数：10
相关论文
共 63 条
[1]  
AKISKAL HS, 1985, ARCH GEN PSYCHIAT, V42, P996
[2]   Increased amygdala activation during mania: A functional magnetic resonance imaging study [J].
Altshuler, L ;
Bookheimer, S ;
Proenza, MA ;
Townsend, J ;
Sabb, F ;
Firestine, A ;
Bartzokis, G ;
Mintz, J ;
Mazziotta, J ;
Cohen, MS .
AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (06) :1211-1213
[3]   Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity [J].
Altshuler, LL ;
Bartzokis, G ;
Grieder, T ;
Curran, J ;
Mintz, J .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (07) :663-664
[4]   The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex [J].
Arnsten, Amy F. T. ;
Datta, Dibyadeep ;
Wang, Min .
MOLECULAR PSYCHIATRY, 2021, 26 (08) :3684-3700
[5]   Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium [J].
Banciu, Adela ;
Banciu, Daniel Dumitru ;
Mustaciosu, Cosmin Catalin ;
Radu, Mihai ;
Cretoiu, Dragos ;
Xiao, Junjie ;
Cretoiu, Sanda Maria ;
Suciu, Nicolae ;
Radu, Beatrice Mihaela .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)
[6]   Personality and bipolar disorder: dissecting state and trait associations between mood and personality [J].
Barnett, J. H. ;
Huang, J. ;
Perlis, R. H. ;
Young, M. M. ;
Rosenbaum, J. F. ;
Nierenberg, A. A. ;
Sachs, G. ;
Nimgaonkar, V. L. ;
Miklowitz, D. J. ;
Smoller, J. W. .
PSYCHOLOGICAL MEDICINE, 2011, 41 (08) :1593-1604
[7]   BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity [J].
Bastos, Clarissa Ribeiro ;
Xavier, Janaina ;
Camerini, Laisa ;
Dewes, Samantha Seibt ;
Moreira, Fernanda Pedrotti ;
Wiener, Carolina David ;
Jansen, Karen ;
Kaster, Manuella Pinto ;
de Mattos Souza, Luciano Dias ;
da Silva, Ricardo Azevedo ;
Oses, Jean Pierre ;
Portela, Luis Valmor ;
Lara, Diogo Rizzato ;
Tovo-Rodrigues, Luciana ;
Ghisleni, Gabriele .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2023, 43 (01) :357-366
[8]   The role of CACNA1C gene and childhood trauma interaction on bipolar disorder [J].
Bastos, Clarissa Ribeiro ;
Tovo-Rodrigues, Luciana ;
Ardais, Ana Paula ;
Xavier, Janaina ;
Vitoria Salerno, Pamela Silva ;
Camerini, Laisa ;
Jansen, Karen ;
de Mattos Souza, Luciano Dias ;
da Silva, Ricardo Azevedo ;
Lara, Diogo Rizzato ;
Ghisleni, Gabriele .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2020, 101
[9]   Gene-based association analysis identifies 190 genes affecting neuroticism [J].
Belonogova, Nadezhda M. ;
Zorkoltseva, Irina, V ;
Tsepilov, Yakov A. ;
Axenovich, Tatiana, I .
SCIENTIFIC REPORTS, 2021, 11 (01)
[10]   Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies [J].
Bi, Bo ;
Che, Dongfang ;
Bai, Yuyin .
TRANSLATIONAL PSYCHIATRY, 2022, 12 (01)
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