Biomimetic Graphene Oxide-Xanthan Gum-Hydroxyapatite Composite Scaffold for Bone Tissue Engineering

被引：4

作者：

Vanpeene, M. ^{[1
]}

Rajesh, R. ^{[2
,3
]}

Ravichandran, Y. Dominic ^{[3
,4
]}

Kuo, Yung-Chih ^{[2
]}

Gure, Gamada ^{[4
]}

机构：

[1] St Gobian Abras, Dept Res & Dev, Paris, France

[2] Natl Chung Cheng Univ, Dept Chem Engn, Chiayi 62102, Taiwan

[3] Karpagam Coll Engn, Dept Sci & Humanities, Coimbatore 641032, Tamil Nadu, India

[4] Wollega Univ, Coll Nat & Computat Sci, Dept Chem, Nekemte, Ethiopia

来源：

CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY | 2023年 / 6卷 / 01期

关键词：

Hydroxyapatite; Graphene oxide; Xanthan gum; Scaffold; Bone tissue engineering; POLYSACCHARIDES; NANOCOMPOSITES; BIOMATERIALS;

D O I：

10.1007/s42250-022-00368-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purpose In recent years, tissue engineering scaffolds have gained popularity as a replacement for metallic/synthetic implants and tissue grafts. Methods A porous tricomponent scaffold of graphene oxide (GO)-xanthan-hydroxyapatite (HAP) was fabricated using the freeze-drying process for bone tissue engineering. Results The physicochemical analysis (FTIR and XRD) revealed that the composite was formed by hydrogen bonding and electrostatic interactions, and also determined a decreased crystallinity, similar to that of real bone apatite. TG/DTA analysis proved the presence of all the raw materials in the scaffold. Morphological studies supported the porous nature of HAP as well as its uniform distribution. The scaffold negatively charged functional group produced positive in vitro results in terms of cell proliferation, biocompatibility, and cell adhesion. Conclusion The positive in vitro results confirmed that the fabricated scaffold materials could be a useful biomaterial for bone tissue engineering.

引用

页码：145 / 152

页数：8

共 31 条

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