Shaping the brain: The emergence of cortical structure and folding

被引：27

作者：

Akula, Shyam K. ^{[1
,2
,3
,4
,5
,6
]}

Exposito-Alonso, David ^{[1
,2
,3
,4
,5
,6
]}

Walsh, Christopher A. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Boston Childrens Hosp, Div Genet & Genom, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[3] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[4] Boston Childrens Hosp, Allen Discovery Ctr Human Brain Evolut, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

DEVELOPMENTAL CELL | 2023年 / 58卷 / 24期

关键词：

OUTER SUBVENTRICULAR ZONE; CELL-CYCLE KINETICS; SONIC-HEDGEHOG GENE; CEREBRAL-CORTEX; RADIAL GLIA; SURFACE-AREA; NEURAL STEM; QUANTITATIVE-ANALYSIS; NEURONAL MIGRATION; PROMOTE EXPANSION;

D O I：

10.1016/j.devcel.2023.11.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cerebral cortex-the brain's covering and largest region-has increased in size and complexity in humans and supports higher cognitive functions such as language and abstract thinking. There is a growing understanding of the human cerebral cortex, including the diversity and number of cell types that it contains, as well as of the developmental mechanisms that shape cortical structure and organization. In this review, we discuss recent progress in our understanding of molecular and cellular processes, as well as mechanical forces, that regulate the folding of the cerebral cortex. Advances in human genetics, coupled with experimental modeling in gyrencephalic species, have provided insights into the central role of cortical progenitors in the gyrification and evolutionary expansion of the cerebral cortex. These studies are essential for understanding the emergence of structural and functional organization during cortical development and the pathogenesis of neurodevelopmental disorders associated with cortical malformations.

引用

页码：2836 / 2849

页数：14

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