Negative impact of immunoparesis in response to anti-SARS-CoV-2 mRNA vaccination of patients with multiple myeloma

被引：0

作者：

Onishi, Akio ^{[1
]}

Matsumura-Kimoto, Yayoi ^{[1
,2
]}

Mizutani, Shinsuke ^{[1
]}

Isa, Reiko ^{[1
]}

Fujino, Takahiro ^{[1
]}

Tsukamoto, Taku ^{[1
]}

Miyashita, Akihiro ^{[1
,3
]}

Okumura, Keita ^{[4
]}

Nishiyama, Daichi ^{[5
]}

Hirakawa, Koichi ^{[5
]}

Shimura, Kazuho ^{[6
]}

Kaneko, Hiroto ^{[6
]}

Kiyota, Miki ^{[7
]}

Kawata, Eri ^{[7
]}

Takahashi, Ryoichi ^{[8
]}

Kobayashi, Tsutomu ^{[9
]}

Uchiyama, Hitoji ^{[9
]}

Uoshima, Nobuhiko ^{[3
]}

Nukui, Yoko ^{[10
]}

Shimura, Yuji ^{[1
]}

Inaba, Tohru ^{[4
,10
]}

Kuroda, Junya ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Med, Div Hematol & Oncol, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

[2] Japan Community Hlth Care Org, Kyoto Kuramaguchi Med Ctr, Dept Hematol, Kyoto, Japan

[3] Japanese Red Cross Kyoto Daini Hosp, Dept Hematol, Kyoto, Japan

[4] Kyoto Prefectural Univ Med, Univ Hosp, Fac Clin Lab, Kyoto, Japan

[5] Fukuchiyama City Hosp, Dept Hematol, Fukuchiyama, Japan

[6] Aiseikai Yamashina Hosp, Dept Hematol, Kyoto, Japan

[7] Matsushita Mem Hosp, Dept Hematol, Moriguchi, Japan

[8] Omihachiman Community Med Ctr, Dept Hematol, Omihachiman, Japan

[9] Japanese Red Cross Kyoto Daiichi Hosp, Dept Hematol, Kyoto, Japan

[10] Kyoto Prefectural Univ Med, Dept Med, Div Infect Control & Mol Lab Med, Kyoto, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024年 / 119卷 / 01期

关键词：

COVID-19; Vaccine; Multiple myeloma; M-protein; Prediction; SARS-COV-2; VACCINES; ANTIBODY;

D O I：

10.1007/s12185-023-03680-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma reduces cellular and humoral immunity. Optimal prediction of antibody response to anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in patients with MM and related disorders is essential to prevent coronavirus disease 2019 (COVID-19) during the SARS-CoV-2 pandemic. This study analyzed the humoral response to the anti-SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine and its associated factor in 83 patients from June to November 2021 at seven member institutions of the Kyoto Clinical Hematology Study Group. SARS-CoV-2 neutralizing antibody (nAb) was measured from 12 to 210 days. The result revealed that 40 (48.2%) patients with MM and 59 (100%) healthy controls became seropositive after vaccination. Receiver operating characteristic curve analysis identified serum immunoglobulin (Ig) M of > 18 mg/dL at vaccination as the optimal threshold level associated with seropositivity in the whole cohort. Moreover, the multivariate analysis identified serum IgM of > 18 mg/dL as the independent predictor for a favorable response. Serum IgA level was positively associated with vaccine response in a sub-cohort. Our findings indicate a significant association between immunoparesis and impaired humoral response against mRNA vaccination, including that against SARS-CoV-2, and that serum non-M-protein Ig levels can serve as surrogate biomarkers of nAb production ability.

引用

页码：62 / 70

页数：9

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