Intention to vaccinate chronic disease children against COVID-19; a multicenter survey

Background Vaccination against severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) has gained recognition as a crucial strategy to prevent and reduce the risk of infection, including emerging variants, due to its proven safety, immunogenicity, and effectiveness. This study aimed to evaluate the vaccination hesitancy (VH) among Egyptian parents towards SARS-CoV-2 vaccination, specifically focusing on parents with chronically ill children.Method A multicentered cross-sectional survey was conducted at outpatient clinics of El-Raml Pediatric Hospital, Ministry of Health and Population (MOHP) in Alexandria, Alexandria Main University Hospital for Maternity and Children (AMUH), Al-Galaa Teaching Hospital, General Organization for Teaching Hospitals and Institutes (GOTHI) Cairo, and Pediatric Department, Menoufia University Hospital from May 1(st) till December 15(th), 2022. Parents of children with chronic diseases were recruited using a simple random sampling technique to respond to the validated Arabic version of parental attitudes about childhood vaccination (PACV).Results In this study, we enrolled 527 caregivers, 55.4% of them were aged 30-39 years old, 85.2% were females, and 46.9% had chronic diseases. Commonly mentioned information sources included television and radio (69.8%), and social media (35.3%). Among the parents studied, 59.6% refused vaccination. The predictors of the PACV score were governorate, Menoufia (beta = 11.30, 95%CI [5.32, 17.27], p < 0.001), study setting, Menoufia University Hospital (beta = -20.07, 95%CI [-25.40, -14.75] and El-Raml Hospital (beta = -10.74, 95%CI [-14.50, -6.98], p < 0.001), income; not enough and loans repaid (beta = 3.18, 95%CI [0.54, 5.82], p = 0.018) and not enough and loans not repaid (beta = 3.57,95%CI [0.08, 7.07], p = 0.045).Conclusions The study reveals geographic and economic factors as predictors of PACV, and emphasizes the need for region-specific interventions and financial barriers to improve vaccine acceptance and child well-being.