Breaking the mold: Overcoming resistance to immune checkpoint inhibitors

被引：4

作者：

Zhao, Menglu ^{[1
]}

Yan, Chun-Yan ^{[1
]}

Wei, Ya-Nan ^{[1
]}

Zhao, Xi-He ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Clin Oncol, Shenyang 110022, Peoples R China

来源：

ANTIVIRAL RESEARCH | 2023年 / 219卷

基金：

中国国家自然科学基金;

关键词：

PD-L1; Drug resistance; Bispecific antibody; Antibody drug conjugate (ADC); TUMOR MUTATIONAL BURDEN; T-CELLS; ANTITUMOR IMMUNITY; CANCER; IMMUNOTHERAPY; BLOCKADE; EFFICACY; RECEPTOR; PD-L1; EXPRESSION;

D O I：

10.1016/j.antiviral.2023.105720

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immune checkpoint blockade-based therapies are effective against a sorts of cancers. However, drug resistance is a problem that cannot be ignored. This review intends to elucidate the mechanisms underlying drug tolerance induced by PD-1/PD-L1 inhibitors, as well as to outline proposed mechanism-based combination therapies and small molecule drugs that target intrinsic immunity and immune checkpoints. According to the differences of patients and types of cancer, the optimization of individualized combination therapy will help to enhance PD-1/ PD-L1-mediated immunoregulation, reduce chemotherapy resistance, and provide new ideas for chemotherapyresistant cancer.

引用

页数：11

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