Effect of Integrated Treatment with Traditional Chinese Medicine on Hashimoto's Thyroiditis Patients

被引:0
作者
Lou, Xudan [1 ]
Huang, Yuxin [1 ]
Qiu, Jieyuzhen [1 ]
Sun, Jiao [1 ]
Gu, Qin [1 ]
Wang, Haidong [1 ]
Tao, Xiaoming [1 ]
Jiang, Cuiping [1 ]
机构
[1] Fudan Univ, Dept Endocrinol, Huadong Hosp, Shanghai 200040, Peoples R China
关键词
CANCER;
D O I
10.1155/2023/5574095
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
What is Known and Objective. To explore the effects of traditional Chinese medicine (TCM) combined with levothyroxine (L-T4) on thyroid autoantibodies, inflammation, and sleep quality in Hashimoto's thyroiditis patients.Methods. Patients were randomly divided into group A and group B. Group A was treated with L-T4 alone, while group B was treated with integrated TCM and L-T4. TCM symptoms were quantified before and after treatment as well as PSQI. Blood samples were taken to detect clinical indicators and thyroid autoantibodies. Cytokines in serum and thyroid tissues were analyzed by ELISA and RT-PCR.Results and Discussion. Totally, 196 patients were enrolled in the study, and there were no differences between group A and group B at the baseline. TCM treatment effectively reduced the levels of TGAb and TPOAb and was a protective factor for the improvement of Hashimoto's thyroiditis antibody titers, p < 0.05. The serum expressions of IL-17A, IL-6, and IFN-gamma in group B after treatment were lower than those in group A and before, while the IL-10 level was raised from the baseline, p < 0.05. Similar results were found in the comparison of IL-17A, IFN-gamma, and IL-10 in thyroid tissues of group A, B, and control, p < 0.05. Besides, with integrated treatment, all TCM symptoms except for poor memory were improved as well as sleep quality and mood, p < 0.05. However, these changes were not observed before and after treatment with L-T4 in group A.What is New and Conclusion. The integrated treatment with TCM had a significant effect on thyroid autoantibodies, inflammation, and sleep quality in Hashimoto's thyroiditis patients and provided a new and effective method for future treatment.
引用
收藏
页数:8
相关论文
共 50 条
[41]   Demographic, clinical, laboratory, ultrasonographic, and cytological features of patients with Hashimoto's thyroiditis: results of a university hospital of 769 patients in Turkey [J].
Erdogan, Mehmet ;
Erdem, Nihat ;
Cetinkalp, Sevki ;
Ozgen, Ahmet Gokhan ;
Saygili, Fusun ;
Yilmaz, Candeger ;
Tuzun, Mehmet ;
Kabalak, Taylan .
ENDOCRINE, 2009, 36 (03) :486-490
[42]   The effect of wet-cupping therapy (hijama) in modulating autoimmune activity of Hashimoto's thyroiditis A pilot controlled study [J].
Obeid, Amal M. ;
Qari, Faiza A. ;
Aljaouni, Soad K. ;
Rohaiem, Sawsan ;
Elsayed, Ahmed A. ;
Alsayyad, Maha M. ;
Okmi, Ezzuddin A. .
SAUDI MEDICAL JOURNAL, 2022, 43 (01) :45-52
[43]   Clinical value of contrast-enhanced ultrasound quantitative analysis for differentiating thyroid lesions in Hashimoto's thyroiditis patients [J].
Yang, Wanting ;
Zhou, Jiehong ;
Yue, Can ;
He, Yushuang ;
Lei, Jianyong ;
Chen, Yong ;
Ma, Buyun .
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2024, 14 (01) :944-957
[44]   FoxP3 promotes lymph node metastasis in patients with papillary thyroid carcinoma complicated with Hashimoto's thyroiditis [J].
Zeng, Rong ;
Lyu, Yi ;
Niu, Heng ;
Yang, Kunxian ;
Yan, Xinmin .
TRANSLATIONAL CANCER RESEARCH, 2020, 9 (03) :1337-1350
[45]   Relationship Between Thyroid Hormonal Status in Patients with a Hypothyroid Form of Hashimoto's Thyroiditis and Iodine Concentrations in Drinking Water [J].
Kasiyan, Olha ;
Tkachenko, Halyna ;
Kurhaluk, Natalia ;
Yurchenko, Svitlana ;
Manenko, Alek .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2022, 200 (01) :59-66
[46]   Thyroid Antibody Status is Associated with Central Lymph Node Metastases in Papillary Thyroid Carcinoma Patients with Hashimoto's Thyroiditis [J].
Wen, Xingzhu ;
Wang, Bin ;
Jin, Qianmei ;
Zhang, Wei ;
Qiu, Ming .
ANNALS OF SURGICAL ONCOLOGY, 2019, 26 (06) :1751-1758
[47]   Meta-Analysis of Chinese Traditional Medicine Bushen Huoxue Prescription for Endometriosis Treatment [J].
Shan, Jing ;
Cheng, Wen ;
Zhai, Dong-xia ;
Zhang, Dan-ying ;
Yao, Rui-pin ;
Bai, Ling-ling ;
Cai, Zai-long ;
Liu, Yu-huan ;
Yu, Chao-qin .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 2017
[48]   Benefit treatment using traditional Chinese medicine in an ulcerative colitis patient: a case report [J].
Chen, C. -s ;
Yang, T. -y ;
Chen, T. -w ;
Chang, Y. -m ;
Chen, C. -k .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2024, 117 (11) :803-805
[49]   Impact of Hashimoto's thyroiditis on radiofrequency ablation for papillary thyroid micro-carcinoma: a cohort study of 391 patients [J].
Lai, Limei ;
Zhou, Chun ;
Liu, Zhenhua ;
Zhang, Jingwen ;
Ni, Xiaofeng ;
Liu, Juan ;
Li, Ning ;
Xia, Shujun ;
Dong, Yijie ;
Zhou, Jianqiao .
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2025, 42 (01)
[50]   Rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes postoperative gastrointestinal function recovery [J].
Cao, Li-Xing ;
Chen, Zhi-Qiang ;
Jiang, Zhi ;
Chen, Qi-Cheng ;
Fan, Xiao-Hua ;
Xia, Shi-Jun ;
Lin, Jin-Xuan ;
Gan, Hua-Chan ;
Wang, Tao ;
Huang, Yang-Xue .
WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (23) :3271-3282