Gadolinium K-edge angiography with a spectral photon counting CT in atherosclerotic rabbits

被引：13

作者：

Boccalini, Sara ^{[1
,2
]}

Dessouky, Riham ^{[3
,4
]}

Rodesch, Pierre-Antoine ^{[3
]}

Lacombe, Hugo ^{[3
]}

Yagil, Yoad ^{[5
]}

Lahoud, Elias ^{[5
]}

Erhard, Klaus ^{[6
]}

Brendel, Bernhard ^{[6
]}

Coulon, Philippe ^{[7
]}

Langlois, Jean-Baptiste ^{[8
]}

Chaput, Frederic ^{[9
]}

Parola, Stephane ^{[9
]}

Boussel, Loic ^{[2
,3
]}

Lerouge, Frederic ^{[9
]}

Si-Mohamed, Salim ^{[2
,3
]}

Douek, Philippe C. ^{[2
,3
]}

机构：

[1] Univ Claude Bernard Lyon 1, Lyon Univ, F-69100 Villeurbanne, France

[2] Hosp Civils Lyon, Louis Pradel Hosp, Dept Cardiovasc & Thorac Radiol, F-69500 Bron, France

[3] Univ Claude Bernard Lyon 1, Lyon Univ, INSA Lyon, UJM St Etienne,CNRS,INSERM,CREATIS UMR 5220,U120, F-69100 Villeurbanne, France

[4] Zagazig Univ, Fac Med, Dept Radiol, Zagazig 44519, Egypt

[5] Philips Med Syst, IL-31004 Haifa, Israel

[6] Philips Res, D-22335 Hamburg, Germany

[7] Philips Healthcare, F-92156 Suresnes, France

[8] CERMEP Ctr Imagerie Vivant, F-69500 Bron, France

[9] Univ Claude Bernard Lyon 1, Univ Lyon, Ecole Normale Super Lyon, Lab Chim,CNRS,UMR 5182, F-69364 Lyon, France

来源：

DIAGNOSTIC AND INTERVENTIONAL IMAGING | 2023年 / 104卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

CT-angiography; Gadolinium based contrast agent; K-edge imaging; Spectral photon counting CT; COMPUTED-TOMOGRAPHY; FEASIBILITY; DEPOSITION; DIAMETER; DENSITY; CALCIUM;

D O I：

10.1016/j.diii.2023.05.002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: The purpose of this study was to investigate the feasibility of gadolinium-K-edge-angiography (angio-Gd-K-edge) with gadolinium-based contrast agents (GBCAs) as obtained with spectral photon counting CT (SPCCT) in atherosclerotic rabbits.Materials and methods: Seven atherosclerotic rabbits underwent angio-SPCCT acquisitions with two GBCAs, with similar intravenous injection protocol. Conventional and angio-Gd-K-edge images were reconstructed with the same parameters. Regions of interest were traced in different locations of the aorta and its branches. Hounsfield unit values, Gd concentrations, signal-to-noise (SNR) and contrast-to-noise (CNR) were calculated and compared. The maximum diameter and the diameter of the aorta in regard to atherosclerotic plaques were measured by two observers. Images were subjectively evaluated regarding vessels' enhancement, artefacts, border sharpness and overall image quality.Results: In the analyzable six rabbits, Gd-K-edge allowed visualization of target vessels and no other structures. HU values and Gd concentrations were greatest in the largest artery (descending aorta, 5.6 +/- 0.8 [SD] mm), and lowest in the smallest (renal arteries, 2.1 +/- 0.3 mm). While greater for conventional images, CNR and SNR were satisfactory for both images (all P < 0.001). For one observer there were no statistically significant differences in either maximum or plaque-diameters (P = 0.45 and all P > 0.05 in post-hoc analysis, respectively). For the second observer, there were no significant differences for images reconstructed with the same parameters (all P < 0.05). All subjective criteria scored higher for conventional images compared to K-edge (all P < 0.01), with the highest scores for enhancement (4.3-4.4 vs. 3.1-3.4).Conclusion: With SPCCT, angio-Gd-K-edge after injection of GBCAs in atherosclerotic rabbits is feasible and allows for angiography-like visualization of small arteries and for the reliable measurement of their diameters.

引用

页码：490 / 499

页数：10

共 34 条

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