Have we overlooked the role of mifepristone for the medical management of tubal ectopic pregnancy?

被引：5
|
作者：
Oltman, Julia [1 ]
Balachander, Sanjana [2 ]
Mol, Ben W. [1 ,3 ,4 ]
Woolner, Andrea M. F. [1 ]
机构：
[1] Univ Aberdeen, Inst Appl Hlth Sci, Aberdeen Ctr Womens Hlth Res, Sch Med Med Sci & Nutr, Aberdeen, Scotland
[2] Monash Univ, Sch Clin Sci Monash Hlth, Clayton, Vic, Australia
[3] Monash Med Ctr, Monash Med Ctr Clayton Obstet & Gynaecol, Clayton, Vic, Australia
[4] Monash Univ, Clayton, Vic, Australia
来源：
HUMAN REPRODUCTION | 2023年 / 38卷 / 08期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
mifepristone; ectopic pregnancy; methotrexate; fallopian tube; RU148; METHOTREXATE; COMBINATION; PHARMACOKINETICS; PROGESTERONE;
D O I：
10.1093/humrep/dead116
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Ectopic pregnancy is a risk of both spontaneous and assisted reproduction pregnancies. The majority of ectopic pregnancies abnormally implant within a fallopian tube (extrauterine pregnancies). In haemodynamically stable women, medical or expectant treatment can be offered. Currently accepted medical treatment is using a drug called methotrexate. However, methotrexate has potential adverse effects, and a significant proportion of women will still require emergency surgery (up to 30%) to remove the ectopic pregnancy. Mifepristone (RU-486) has anti-progesterone effects and has a role in managing intrauterine pregnancy loss and termination of pregnancy. On reviewing the literature and given progesterone's pivotal role in sustaining pregnancy, we propose that we may have overlooked the role of mifepristone in the medical management of tubal ectopic pregnancy in haemodynamically stable women.
引用
收藏
页码：1445 / 1448
页数：4
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