Diversified Synthesis of All-Carbon Quaternary gem-Difluorinated Cyclopropanes via Copper-Catalyzed Cross-Coupling

被引：13

作者：

Li, Bin ^{[1
,2
,3
]}

Shi, Jiang-Ling ^{[1
,2
,3
]}

Xia, Ying ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp 4, Chengdu 610041, Peoples R China

[3] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 15期

关键词：

CYCLOADDITION; ALKYNES;

D O I：

10.1021/acs.orglett.3c00751

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of all-carbon quaternary centers in small-ring systems is important but challenging in organic synthesis. Herein, by taking gem-difluorocyclopropyl bromides (DFCBs) as a type of general and versatile building block, we developed a practical method for building all-carbon quaternary centers in gem-difluorinated cyclopropanes (DFCs). The reaction relies on the involvement of a gem-difluorocyclopropyl radical intermediate, which can couple with a wide range of nucleophiles under copper catalysis.

引用

页码：2674 / 2679

页数：6

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