Treatment Strategy of Uncontrolled Chronic Rhinosinusitis with Nasal Polyps: A Review of Recent Evidence

被引:9
作者
Kim, Sung-Dong [1 ]
Cho, Kyu-Sup [1 ]
机构
[1] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Otorhinolaryngol, 179 Gudeok Ro, Pusan 602739, South Korea
关键词
chronic rhinosinusitis; nasal polyps; endotype; pharmacotherapy; biologics; surgery; REFRACTORY CHRONIC RHINOSINUSITIS; PLACEBO-CONTROLLED TRIAL; FRONTAL-SINUS SURGERY; NEUTROPHILIC INFLAMMATION; SEVERE ASTHMA; DOUBLE-BLIND; LONG-TERM; EFFICACY; IGE; ENDOTYPES;
D O I
10.3390/ijms24055015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chronic rhinosinusitis (CRS) is recognized as a heterogeneous disease with a wide range of clinical features, resulting in significant morbidity and cost to the healthcare system. While the phenotypic classification is determined by the presence or absence of nasal polyps and comorbidities, the endotype classification has been established based on molecular biomarkers or specific mechanisms. Research on CRS has now developed based on information based on three major endotypes: types 1, 2, and 3. Recently, biological therapies targeting type 2 inflammation have been clinically expanded and may be applied to other inflammatory endotypes in the future. The purpose of this review is to discuss the treatment options according to the type of CRS and summarize recent studies on new therapeutic approaches for patients with uncontrolled CRS with nasal polyps.
引用
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页数:14
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