A simultaneous EEG-fMRI study of thalamic load-dependent working memory delay period activity

被引:6
作者
Gomes, Bernard A. [1 ]
Plaska, Chelsea Reichert [2 ]
Ortega, Jefferson [3 ]
Ellmore, Timothy M. [1 ,2 ,3 ]
机构
[1] CUNY, Program Cognit Neurosci, Grad Ctr, New York, NY 10017 USA
[2] CUNY, Doctoral Program Behav & Cognit Neurosci, Grad Ctr, New York, NY 10017 USA
[3] CUNY City Coll, Dept Psychol, New York, NY 10031 USA
基金
美国国家卫生研究院;
关键词
thalamus; delay activity; working memory; simultaneous EEG-fMRI; source estimation; PREFRONTAL CORTEX; RESPONSE-INHIBITION; BRAIN; MAINTENANCE; PERFORMANCE; MECHANISMS; NUCLEUS; SPACE;
D O I
10.3389/fnbeh.2023.1132061
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Introduction: Working memory (WM) is an essential component of executive functions which depend on maintaining task-related information online for brief periods in both the presence and absence of interfering stimuli. Active maintenance occurs during the WM delay period, the time between stimulus encoding and subsequent retrieval. Previous studies have extensively documented prefrontal and posterior parietal cortex activity during the WM delay period, but the role of subcortical structures including the thalamus remains to be fully elucidated, especially in humans. Methods: Using a simultaneous electroencephalogram (EEG)-functional magnetic resonance imaging (fMRI) approach, we investigated the role of the thalamus during the WM delay period in a modified Sternberg paradigm following low and high memory load encoding of naturalistic scenes. During the delay, participants passively viewed scrambled scenes containing similar color and spatial frequency to serve as a perceptual baseline. Individual source estimation was weighted by the location of the thalamic fMRI signal relative to the WM delay period onset. Results: The effects memory load on maintenance were observed bilaterally in thalamus with higher EEG source amplitudes in the low compared to high load condition occurring 160-390 ms after the onset of the delay period. Conclusion: The main finding that thalamic activation was elevated during the low compared to high condition despite similar duration of perceptual input and upcoming motor requirements suggests a capacity-limited role for sensory filtering of the thalamus during consolidation of stimuli into WM, where the highest activity occurs when fewer stimuli need to be maintained in the presence of interfering perceptual stimuli during the delay. The results are discussed in the context of theories regarding the role of the thalamus in sensory gating during working memory.
引用
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页数:13
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