Exploring the Role of Ag Nanoparticle Distribution in Novel pH-Sensitive Nanofibers Containing Hyaluronic Acid for Enhanced Wound Healing with Sustained Curcumin Release

被引：3
作者：
Sayyar, Zahra [1 ]
Sadigh, Mahsa Khadem [2 ]
机构：
[1] Univ Bonab, Dept Chem Engn, Bonab 5551395133, Iran
[2] Univ Bonab, Dept Laser & Opt Engn, Bonab 5551395133, Iran
来源：
FIBERS AND POLYMERS | 2024年 / 25卷 / 04期
关键词：
Nanofibers; Ag nanoparticles; Curcumin; Hyaluronic acid; Drug release; Wound healing; HYDROGELS; CHITOSAN;
D O I：
10.1007/s12221-024-00509-4
中图分类号：
TB3 [工程材料学]; TS1 [纺织工业、染整工业];
学科分类号：
0805 ; 080502 ; 0821 ;
摘要：
The use of nanofiber patches has received considerable attention as a promising solution for overcoming challenges in drug delivery. In this study, silver nanoparticles (Ag NPs) were incorporated in chitosan (CS), hyaluronic acid (HYA), and polyvinyl alcohol (PVA) to form nanofibers (namely, the CS/HYA/PVA-Ag nanofiber) for the controllable release of curcumin (CUR). The CUR release from the CS/HYA/PVA-Ag nanofibers consistently happened sustainably. Therefore, the prepared CS/HYA/PVA-Ag nanofibers show great promise in terms of their ability to expand the field of pH-dependent transdermal drug delivery (TDD) and sustainably release drugs. Additionally, the scratch assay results of these nanofibers further support their potential applications in wound healing.
引用
收藏
页码：1163 / 1176
页数：14
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