Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel

被引：32

作者：

Zhang, Shengnan ^{[1
]}

Ye, Taiqiang ^{[1
]}

Liu, Yibin ^{[1
]}

Hou, Guige ^{[2
]}

Wang, Qibao ^{[3
]}

Zhao, Fenglan ^{[1
]}

Li, Feng ^{[1
]}

Meng, Qingguo ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Minist Educ,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China

[2] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China

[3] Jining Med Univ, Sch Biol Sci, Rizhao 276800, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 22期

关键词：

paclitaxel; anticancer mechanism; total synthesis; semi-synthesis; biosynthesis; TAXOL-PRODUCING FUNGUS; FORMAL TOTAL-SYNTHESIS; 1ST TOTAL-SYNTHESIS; ENDOPHYTIC FUNGUS; BACCATIN III; STEREOCONTROLLED SYNTHESIS; CELLULAR SENESCENCE; TAXANE PRODUCTION; PINENE PATH; SIDE-CHAIN;

D O I：

10.3390/molecules28227517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paclitaxel, a natural secondary metabolite isolated and purified from the bark of the Taxus tree, is considered one of the most successful natural anticancer drugs due to its low toxicity, high potency and broad-spectrum anticancer activity. Taxus trees are scarce and slow-growing, and with extremely low paclitaxel content, the contradiction between supply and demand in the market is becoming more and more intense. Therefore, researchers have tried to obtain paclitaxel by various methods such as chemical synthesis, artificial culture, microbial fermentation and tissue cell culture to meet the clinical demand for this drug. This paper provides a comprehensive overview of paclitaxel extraction, combination therapy, total synthesis, semi-synthesis and biosynthesis in recent years and provides an outlook, aiming to provide a theoretical basis and reference for further research on the production and application of paclitaxel in the future.

引用

页数：29

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