Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review

被引：21
作者：
Bertoni, Camilla [1 ]
Abodi, Martina [1 ]
D'Oria, Veronica [2 ]
Milani, Gregorio P. [2 ,3 ]
Agostoni, Carlo [2 ,3 ]
Mazzocchi, Alessandra [3 ]
机构：
[1] Univ Milan, Dept Vet Sci Hlth Anim Prod & Food Safety, I-20122 Milan, Italy
[2] Fdn IRCCS CaGranda Osped Maggiore Policlin, Pediat Area, I-20122 Milan, Italy
[3] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期
关键词：
alpha-linolenic acid; hempseed oil; cardiovascular events; LDL-cholesterol; TC-cholesterol; cardioprotective effect; heart disorders; linoleic acid; N-3; FATTY-ACIDS; POSTMYOCARDIAL INFARCTION PATIENTS; DOCOSAHEXAENOIC ACID; MEDITERRANEAN DIET; MYOCARDIAL-INFARCTION; RISK-FACTORS; METAANALYSIS; DISEASE; CONSUMPTION; OMEGA-3;
D O I：
10.3390/ijms241814319
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cardiovascular diseases (CVDs) represent the leading cause of global mortality with 1.7 million deaths a year. One of the alternative systems to drug therapy to minimize the risk of CVDs is represented by alpha-linolenic acid (ALA), an essential fatty acid of the omega-3 series, known for its cholesterol-lowering effect. The main purpose of this review is to analyze the effects of ALA and investigate the relevant omega-6/omega-3 ratio in order to maintain functionally beneficial effects. Concerning the lipid-lowering preventive effects, ALA may favorably affect the values of LDL-C and triglycerides in both adult and pediatric populations. Furthermore, ALA has shown protective effects against hypertension, contributing to balancing blood pressure through customary diet. According to the 2009 EFSA statement, dietary ALA may contribute to reducing the risk of CVDs, thanks to anti-hypertensive, anti-atherosclerotic and cardioprotective effects.
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页数：14
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