Advancing Strongyloides omics data: bridging the gap with Caenorhabditis elegans

被引：3

作者：

Al-Jawabreh, Reem ^{[1
]}

Lastik, Dominika ^{[1
]}

Mckenzie, Darrin ^{[2
]}

Reynolds, Kieran ^{[1
]}

Suleiman, Mona ^{[1
]}

Mousley, Angela ^{[2
]}

Atkinson, Louise ^{[2
]}

Hunt, Vicky ^{[1
]}

机构：

[1] Univ Bath, Dept Life Sci, Bath BA2 7AY, England

[2] Queens Univ Belfast, Belfast BT9 5DL, North Ireland

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2024年 / 379卷 / 1894期

关键词：

Strongyloides; genomics; transcriptomics; proteomics; small RNA; transposable elements; EXTRACELLULAR VESICLES; PARASITIC NEMATODE; DEVELOPMENTAL-STAGES; PROTEOMIC ANALYSIS; SMALL RNAS; TRANSPOSABLE ELEMENTS; GENE-EXPRESSION; WEB SERVER; STERCORALIS; IDENTIFICATION;

D O I：

10.1098/rstb.2022.0437

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Among nematodes, the free-living model organism Caenorhabditis elegans boasts the most advanced portfolio of high-quality omics data. The resources available for parasitic nematodes, including Strongyloides spp., however, are lagging behind. While C. elegans remains the most tractable nematode and has significantly advanced our understanding of many facets of nematode biology, C. elegans is not suitable as a surrogate system for the study of parasitism and it is important that we improve the omics resources available for parasitic nematode species. Here, we review the omics data available for Strongyloides spp. and compare the available resources to those for C. elegans and other parasitic nematodes. The advancements in C. elegans omics offer a blueprint for improving omics-led research in Strongyloides. We suggest areas of priority for future research that will pave the way for expansions in omics resources and technologies.This article is part of the Theo Murphy meeting issue 'Strongyloides: omics to worm-free populations'.

引用

页数：22

共 211 条

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