Fast high-resolution prospective motion correction for single-voxel spectroscopy

Purpose: To develop a fast high-resolution image-based motion correction method using spiral navigators with multislice-to-volume registration. Methods: A semi-LASER sequence was modified to include a multislice spiral navigator for prospective motion correction (similar to 305 ms including acquisition, processing, and feedback) as well as shim and frequency navigators for prospective shim and frequency correction (similar to 100 ms for each). MR spectra were obtained in the prefrontal cortex in five healthy subjects at 3T with and without prospective motion and shim correction. The effect of key navigator parameters (number of slices, image resolution, and excitation flip angle) on registration accuracy was assessed using simulations. Results: Without prospective motion and shim correction, spectral quality degraded significantly in the presence of voluntary motion. In contrast, with prospective motion and shim correction, spectral quality was improved (metabolite linewidth=6.70.6Hz, SNR=67 +/- 9) and in good agreement with baseline data without motion (metabolite linewidth=6.9 +/- 0.9Hz, SNR=73 +/- 9). In addition, there was no significant difference in metabolites concentrations measured without motion and with prospective motion and shim correction in the presence of motion. Simulations showed that the registration precision was comparable when using three navigator slices with 3 mm resolution and when using the entire volume (all slices) with 8 mm resolution. Conclusion: The proposed motion correction scheme allows fast and precise prospective motion and shim correction for single-voxel spectroscopy at 3T. With 3 mm resolution, only a few navigator slices are necessary to achieve excellent motion correction performance.