Genome-wide identification of ATP-binding cassette transporter B subfamily, focusing on its structure, evolution and rearrangement in ciliates

被引:6
作者
Zhang, Xue [1 ,2 ]
Zhao, Yan [3 ]
Zheng, Weibo [4 ]
Nan, Bei [1 ,2 ]
Fu, Jinyu [1 ,2 ]
Qiao, Yu [1 ,2 ]
Zufall, Rebecca A. [5 ]
Gao, Feng [1 ,2 ,6 ]
Yan, Ying [1 ,2 ]
机构
[1] Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Shandong, Peoples R China
[2] Minist Educ, Key Lab Evolut & Marine Biodivers OUC, Qingdao 266003, Peoples R China
[3] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
[4] Ludong Univ, Sch Life Sci, Yantai 264025, Shandong, Peoples R China
[5] Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA
[6] Lab Marine Biol & Biotechnol, Laoshan Lab, Qingdao 266237, Peoples R China
关键词
ABCB transporter gene; gene family evolution; gene rearrangement; ciliate; ABC TRANSPORTERS; AUXIN TRANSPORT; PROTEIN; GENE; RESISTANCE; INSIGHTS; MICRONUCLEAR; ORGANIZATION; DIVERSITY; PATTERNS;
D O I
10.1098/rsob.230111
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
ATP-binding cassette subfamily B (ABCB) has been implicated in various essential functions such as multidrug resistance, auxin transport and heavy metal tolerance in animals and plants. However, the functions, the genomic distribution and the evolutionary history have not been characterized systematically in lower eukaryotes. As a lineage of highly specialized unicellular eukaryotes, ciliates have extremely diverse genomic features including nuclear dimorphism. To further understand the genomic structure and evolutionary history of this gene family, we investigated the ABCB gene subfamily in 11 ciliates. The results demonstrate that there is evidence of substantial gene duplication, which has occurred by different mechanisms in different species. These gene duplicates show consistent purifying selection, suggesting functional constraint, in all but one species, where positive selection may be acting to generate novel function. We also compare the gene structures in the micronuclear and macronuclear genomes and find no gene scrambling during genome rearrangement, despite the abundance of such scrambling in two of our focal species. These results lay the foundation for future analyses of the function of these genes and the mechanisms responsible for their evolution across diverse eukaryotic lineages.
引用
收藏
页数:11
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