Organophotocatalytic Radical-Polar Cross-Coupling of Styrylboronic Acids and Redox-Active Esters

被引：1

作者：

Brals, Jeremy ^{[1
]}

D'Arcy-Evans, Nicholas ^{[1
]}

Mcguire, Thomas M. ^{[2
]}

Watson, Allan J. B. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, Purdie Bldg,North Haugh, St Andrews KY16 9ST, Scotland

[2] AstraZeneca, Darwin Bldg,Unit 310,Cambridge Sci Pk,Milton Rd, Cambridge CB4 0WG, England

来源：

SYNLETT | 2024年 / 35卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

esters; styrylboronic acids; photocatalysis; radical-polar cross-coupling; EOSIN Y; PHOTOREDOX; ISOMERIZATION; OXIDATION; ALKENES;

D O I：

10.1055/a-2179-6570

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the development of a radical-polar cross -coupling reaction using styrylboronic acids and redox-active esters under organophotoredox catalysis. The reaction proceeds through a formal polarity-mismatched radical addition. The use of an organic photocatalyst permitted very low loadings of the electron-shuttle additive and accelerated reaction times compared with established processes. The scope of the reaction was explored, and the utility of the products is demonstrated.

引用

页码：205 / 208

页数：4