Causes and Prevention of Early-Onset Colorectal Cancer

被引：14

作者：

Adigun, Aisha O. ^{[1
]}

Adebile, Temitayo M. ^{[2
,3
]}

Okoye, Chiugo ^{[4
]}

Ogundipe, Taiwo I. ^{[5
]}

Ajekigbe, Omolola R. ^{[6
]}

Mbaezue, Rheiner N. ^{[7
]}

Okobi, Okelue E. ^{[8
,9
,10
]}

机构：

[1] Univ Louisville, Infect Dis, Louisville, KY 40292 USA

[2] Georgia Southern Univ, Publ Hlth, Statesboro, GA USA

[3] Boston Med Ctr, Nephrol, Boston, MA USA

[4] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CA USA

[5] Palm Coast Urgent Care, Internal Med, Orlando, FL USA

[6] Ladoke Akintola Univ Technol, Family Med, Ogbomosho, Nigeria

[7] Dept Hlth, Hlth Serv, Cape Town, South Africa

[8] Larkin Community Hosp Palm Springs Campus, Family Med, Hialeah, FL USA

[9] Medficient Hlth Syst, Family Med, Laurel, MS USA

[10] Lakeside Med Ctr, Family Med, Belle Glade, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 09期

关键词：

diet; lifestyle; risk factors; prevention; colorectal cancer; sporadic; early; -onset; YOUNG-ADULTS; RISK; ADOLESCENTS; PREVALENCE; MUTATIONS; MORTALITY; FEATURES; OBESITY; DIET;

D O I：

10.7759/cureus.45095

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sporadic colorectal cancer (CRC) has historically been considered a disease of the elderly. However, early -onset colorectal cancer (eoCRC) incidence and prevalence have steadily increased over the last few decades, highlighting the critical need for a comprehensive understanding of its causes and prevention. This research examines the numerous factors contributing to the increasing incidence of eoCRC. These factors include a combination of genetic predispositions and environmental effects. We also investigate the impact of modifiable lifestyle factors like obesity, physical inactivity, and an unhealthy diet on eoCRC risk. Understanding these factors is critical in developing future diagnostic, prognostic, disease monitoring, and therapy planning strategies in managing eoCRC and will help optimize guidelines for CRC screening.

引用

页数：11

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