Neoantigens in cancer immunotherapy: quantity vs. quality

被引：4

作者：

Wolf, Yochai ^{[1
]}

Sameuls, Yardena ^{[2
,3
]}

机构：

[1] Sheba Med Ctr, Ella Lemelbaum Inst Immunooncol, IL-5265601 Ramat Gan, Israel

[2] Tel Aviv Univ, Fac Med, Dept Pathol, Tel Aviv, Israel

[3] Weizmann Inst Sci, Dept Mol Cell Biol, IL-761000 Rehovot, Israel

来源：

MOLECULAR ONCOLOGY | 2023年 / 17卷 / 08期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

cancer immunotherapy; cancer microbiome; neoantigens; post-translational modifications; recurrent mutations; tumor heterogeneity; THERAPY; IMMUNITY;

D O I：

10.1002/1878-0261.13483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Traditional immunotherapies provide clinical benefits to only a few patients with solid tumors, highlighting the urgent need for more effective approaches. Traditional immunotherapies rely on the presentation of cancer antigens, with neoantigens being highly important in this context as they are specific to malignant tissue but not healthy tissue. The quantity of neoantigens is often associated with clinical benefit, but it cannot fully explain or predict patient response. In this Viewpoint, we highlight several qualitative aspects that should be considered in neoantigen-based therapy. We emphasize the distinction between private and recurrent neoantigens, discuss the importance of neoantigen clonality, and describe new subtypes of neopeptides that further diversify the potential of neoantigens in immunotherapy.

引用

页码：1457 / 1459

页数：3

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