Atom-efficient arylation of N-tosylimines mediated by cooperative ZnAr2/Zn(C6F5)2 combinations

被引：3

作者：

Borys, Andryj M. M. ^{[1
]}

Kunzmann, Tim ^{[1
]}

Gil-Negrete, Jose M. M. ^{[1
]}

Hevia, Eva ^{[1
]}

机构：

[1] Univ Bern, Dept Chem Biochem & Pharm, CH-3012 Bern, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 49期

关键词：

DEEP EUTECTIC SOLVENTS; REAGENTS; IMINES; ORGANOLITHIUM; BUTYLLITHIUM; ZINCATION; ANISOLE; ZINC;

D O I：

10.1039/d3cc01490h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By combining the Lewis acid Zn(C6F5)(2) with nucleophilic diarylzinc (ZnAr2) reagents, we report the atom-efficient arylation of N-tosylimines under mild conditions. Mechanistic studies through the isolation of key intermediates reveal how the two zinc species act cooperatively to activate the imine substrate and regenerate the ZnAr2 reagent, enabling a limiting 50 mol% to be employed.

引用

页码：7583 / 7586

页数：4

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