Comparative Lipidomic Analysis Reveals the Lactational Changes in the Lipid Profiles of Chinese Human Milk

被引：3
作者：
Wu, Danjie [1 ]
Zhang, Le [1 ,2 ]
Tan, Chin Ping [1 ,3 ]
Zheng, Zhaojun [1 ]
Liu, Yuanfa [1 ]
机构：
[1] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Natl Engn Res Ctr Cereal Fermentat & Food Biomfg, State Key Lab Food Sci & Technol,Sch Food Sci & Te, Wuxi 214122, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Wuxi Childrens Hosp, Dept Neonatol, Wuxi 214023, Jiangsu, Peoples R China
[3] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Technol, Serdang 43400, Malaysia
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2023年 / 71卷 / 13期
基金：
中国国家自然科学基金;
关键词：
human milk; lactation; lipid profile; lipidomic; FATTY-ACID-COMPOSITION; BREAST-MILK; LIQUID-CHROMATOGRAPHY; MOTHERS;
D O I：
10.1021/acs.jafc.2c08857
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Human milk (HM) lipid plays a crucial role in infant development, whereas its complex lipid profiles and its dynamic changes during prolonged lactation have not been investigated yet. Comparative lipidomic analyses were employed in investigating the lipid profiles of breast milk covering all lactation stages herein. Results revealed significant differences between colostrum and the remaining lactations. A total of 237 species of glycerolipids (GLs) and 231 phospholipids (PLs) were identified. Colostrum had the most abundant lipid species and was enriched with triacylglycerols (TGs) with a high molecular weight. TG(17:1/18:1/24:1), TG(24:1/24:1/26:1), TG(24:0/24:1/26:1), and SM(d20:1/14:1) were characteristic lipids of colostrum. Differential lipid species which were responsible for distinguishing the adjacent lactations were also indicated. Our findings can help deepen the overall understanding of HM lipid profiles and its dynamic changes, which will facilitate the development of infant formulas suitable for Chinese babies in diverse age groups.
引用
收藏
页码：5403 / 5416
页数：14
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