How Structure-Function Relationships of 1,4-Naphthoquinones Combat Antimicrobial Resistance in Multidrug-Resistant (MDR) Pathogens

被引:12
作者
Mone, Nishigandha S. [1 ]
Syed, Sahil [1 ]
Ravichandiran, Palanisamy [2 ,3 ,4 ]
Satpute, Surekha K. [1 ]
Kim, A. Rhan [3 ]
Yoo, Dong Jin [2 ,3 ]
机构
[1] Savitribai Phule Pune Univ, Dept Microbiol, Pune 411007, Maharashtra, India
[2] Jeonbuk Natl Univ, R&D Educ Ctr Whole Life Cycle R&D Fuel Cell Syst, Jeonju 54896, Jeonrabug Do, South Korea
[3] Jeonbuk Natl Univ, Hydrogen & Fuel Cell Res Ctr, Dept Energy Storage Convers Engn BK21 FOUR, Dept Life Sci,Grad Sch, Jeonju 54896, Jeonrabug Do, South Korea
[4] Hindustan Petr Corp Ltd, HP Green R&D Ctr, Analyt, KIADB Ind Area, Bengaluru 562114, Karnataka, India
基金
新加坡国家研究基金会;
关键词
Antimicrobial resistance; ESKAPE pathogens; Mechanisms; Multidrug resistance; Naphthoquinones; MOLECULAR DOCKING; DNA GYRASE; ANTIBACTERIAL; ANTIFUNGAL; ANTIBIOTICS; DERIVATIVES; INHIBITION; BACTERIA; LAPACHOL; GROWTH;
D O I
10.1002/cmdc.202200471
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Antimicrobial resistance (AMR) is one of the top ten health-related threats worldwide. Among several antimicrobial agents, naphthoquinones (NQs) of plant/chemical origin possess enormous structural and functional diversity and are effective against multidrug-resistant (MDR) pathogens. 1,4-NQs possess alkyl, hydroxyl, halide, and metal groups as side chains on their double-ring structure, predominantly at the C-2, C-3, C-5, and C-8 positions. Among 1,4-NQs, hydroxyl groups at either C-2 or C-5 exhibit significant antibacterial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. (ESKAPE) and MDR categories. 1,4-NQs exhibit antibacterial activities like plasmids curing, reactive oxygen species generation, efflux pumps inhibition, anti-DNA gyrase activity, membrane permeabilization, and biofilm inhibition. This review emphasizes the structure-function relationships of 1,4-NQs against ESKAPE and MDR pathogens based on a literature review of studies published in the last 15 years. Overall, 1,4-NQs have great potential for counteracting the antimicrobial resistance of MDR pathogens.
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页数:24
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