RNA-Guided RNA Pseudouridylation and 2'-O-Methylation

被引：0

作者：

Adachi, Hironori ^{[1
]}

Chen, Jonathan L. ^{[1
]}

Leeder, W. -Matthias ^{[2
]}

Morais, Pedro ^{[3
]}

Yu, Yi-Tao ^{[1
,3
]}

机构：

[1] Univ Rochester Med Ctr, Ctr RNA Biol, Dept Biochem & Biophys, Rochester, NY 14642 USA

[2] ProQR Therapeut, NL-2333 CK Leiden, Netherlands

[3] Bayer AG, Res & Dev, Pharmaceut, D-42113 Wuppertal, Germany

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2024年 / 64卷 / 3-4期

关键词：

Pseudouridylation; 2'-O-methylation; Box H/ACA snoRNP; Box C/D snoRNP; Targeted RNA modification; SITE RECOGNITION REGION; MESSENGER-RNA; RIBOSOMAL-RNA; U2; SNRNA; MODIFIED NUCLEOTIDES; CRYSTAL-STRUCTURE; PRERIBOSOMAL RNA; STRUCTURAL BASIS; HIGH-THROUGHPUT; SUBSTRATE RNA;

D O I：

10.1002/ijch.202400005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

RNA-guided RNA modifications, including pseudouridylation and 2 '-O-methylation, are naturally occurring processes that introduce pseudouridines (psi) and 2'-O-methylated residues (2'-O-Me) into various types of RNA. This modification is orchestrated by two distinct families of ribonucleoprotein complexes: Box H/ACA RNP and Box C/D RNP. Each complex comprises a unique guide (g)RNA (Box H/ACA gRNA or Box C/D gRNA) and a set of core proteins responsible for pseudouridylation and 2'-O-methylation, respectively. The specificity of these modifications is conferred by base-pairing of Box H/ACA gRNA and Box C/D gRNA with their RNA substrates. Here, we discuss the mechanism and function of RNA-guided pseudouridylation and 2'-O-methylation. image

引用

页数：12

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