Biomarkers for Diabetic Nephropathy with a Focus on Kidney Injury Molecule-1 (KIM-1)

被引：3
作者：
Khonsha, Fatemeh [1 ,2 ,3 ]
Valilo, Mohammad [4 ]
Nejabati, Hamid-Reza [2 ,3 ,5 ]
Rahmati-Yamchi, Mohammad [2 ,3 ]
Mota, Ali [1 ,2 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Med, Clin Labs, Tabriz, Iran
[4] Urmia Univ Med Sci, Fac Med, Dept Biochem, Orumiyeh, Iran
[5] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
来源：
CURRENT DIABETES REVIEWS | 2024年 / 20卷 / 01期
关键词：
Diabetes; nephropathy; diabetic nephropathy; kidney injury molecule-1; end-stage renal disease (ESRD); renal injury; GELATINASE-ASSOCIATED LIPOCALIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RENAL INJURY; ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; URINARY KIM-1; NITRIC-OXIDE; EARLY-STAGE; TYPE-2; NGAL;
D O I：
10.2174/1573399819666230328151108
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic Nephropathy (DN), with an increasing rate of mortality and morbidity, is considered the main cause of End-Stage Renal Disease (ESRD). A wide spectrum of biomarkers exist for early detection of DN, but they suffer from low specificity and sensitivity, indicating the urgent demand for finding more effective biomarkers. Also, the pathophysiology of tubular damage and its relation to DN are not yet completely understood. Kidney Injury Molecule-1 (KIM-1) is a protein that is expressed at substantially low contents in the kidney under physiological conditions. A number of reports have demonstrated the close relationship between urine and tissue KIM-1 levels and kidney disorders. KIM-1 is known as a biomarker for diabetic nephropathy and renal injury. In this study, we aim to review the potential clinical and pathological roles of KIM-1 in diabetic nephropathy.
引用
收藏
页码：67 / 75
页数：9
相关论文
共 99 条
  • [1] Abe T., 2018, Marker for determining diabetic nephropathy
  • [2] KIM-1 expression in kidney allograft biopsies: Improving the gold standard
    Abulezz, S.
    [J]. KIDNEY INTERNATIONAL, 2008, 73 (05) : 522 - 523
  • [3] Diabetic Kidney Disease Challenges, Progress, and Possibilities
    Alicic, Radica Z.
    Rooney, Michele T.
    Tuttle, Katherine R.
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 12 (12): : 2032 - 2045
  • [4] Incidence of complications in young-onset diabetes: Comparing type 2 with type 1 (the young diab study)
    Amutha, Anandakumar
    Anjana, Ranjit Mohan
    Venkatesan, Ulagamathesan
    Ranjani, Harish
    Unnikrishnan, Ranjit
    Narayan, K. M. Venkat
    Mohan, Viswanathan
    Ali, Mohammed K.
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2017, 123 : 1 - 8
  • [5] [Anonymous], 2019, Am J Kidney Dis, DOI 10.1053/j.ajkd.2019.09.002
  • [6] Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy
    Banba, N
    Nakamura, T
    Matsumura, M
    Kuroda, H
    Hattori, Y
    Kasai, K
    [J]. KIDNEY INTERNATIONAL, 2000, 58 (02) : 684 - 690
  • [7] Renal tubulointerstitial expansion is associated with endothelial dysfunction and inflammation in type 1 diabetes
    Bangstad, Hans-Jacob
    Seljeflot, Ingebjorg
    Berg, Tore J.
    Hanssen, Kristian F.
    [J]. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2009, 69 (01) : 138 - 144
  • [8] Early term effect of ureterorenoscopy (URS) on the Kidney: research measuring NGAL, KIM-1, FABP and CYS C levels in urine
    Benli, Erdal
    Ayyildiz, Sema Nur
    Cirrik, Selma
    Noyan, Tevfik
    Ayyildiz, Ali
    Cirakoglu, Abdullah
    [J]. INTERNATIONAL BRAZ J UROL, 2017, 43 (05): : 887 - 895
  • [9] Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes
    Betz, Boris B.
    Jenks, Sara J.
    Cronshaw, Andrew D.
    Lamont, Douglas J.
    Cairns, Carolynn
    Manning, Jonathan R.
    Goddard, Jane
    Webb, David J.
    Mullins, John J.
    Hughes, Jeremy
    McLachlan, Stela
    Strachan, Mark W. J.
    Price, Jackie F.
    Conway, Bryan R.
    [J]. KIDNEY INTERNATIONAL, 2016, 89 (05) : 1125 - 1135
  • [10] Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study
    Bhavsar, Nrupen A.
    Koettgen, Anna
    Coresh, Josef
    Astor, Brad C.
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2012, 60 (02) : 233 - 240
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