Biomarkers for Diabetic Nephropathy with a Focus on Kidney Injury Molecule-1 (KIM-1)

被引：6
作者：
Khonsha, Fatemeh [1 ,2 ,3 ]
Valilo, Mohammad [4 ]
Nejabati, Hamid-Reza [2 ,3 ,5 ]
Rahmati-Yamchi, Mohammad [2 ,3 ]
Mota, Ali [1 ,2 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Med, Clin Labs, Tabriz, Iran
[4] Urmia Univ Med Sci, Fac Med, Dept Biochem, Orumiyeh, Iran
[5] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
来源：
CURRENT DIABETES REVIEWS | 2024年 / 20卷 / 01期
关键词：
Diabetes; nephropathy; diabetic nephropathy; kidney injury molecule-1; end-stage renal disease (ESRD); renal injury; GELATINASE-ASSOCIATED LIPOCALIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RENAL INJURY; ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; URINARY KIM-1; NITRIC-OXIDE; EARLY-STAGE; TYPE-2; NGAL;
D O I：
10.2174/1573399819666230328151108
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic Nephropathy (DN), with an increasing rate of mortality and morbidity, is considered the main cause of End-Stage Renal Disease (ESRD). A wide spectrum of biomarkers exist for early detection of DN, but they suffer from low specificity and sensitivity, indicating the urgent demand for finding more effective biomarkers. Also, the pathophysiology of tubular damage and its relation to DN are not yet completely understood. Kidney Injury Molecule-1 (KIM-1) is a protein that is expressed at substantially low contents in the kidney under physiological conditions. A number of reports have demonstrated the close relationship between urine and tissue KIM-1 levels and kidney disorders. KIM-1 is known as a biomarker for diabetic nephropathy and renal injury. In this study, we aim to review the potential clinical and pathological roles of KIM-1 in diabetic nephropathy.
引用
收藏
页码：67 / 75
页数：9
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