RuPHOX-Ru catalyzed asymmetric Guerbet reaction of secondary alcohols with primary alcohols

被引：3

作者：

He, Jingli ^{[1
]}

Li, Ruhui ^{[1
]}

Kou, Xuezhen ^{[1
]}

Fu, Daxu ^{[2
]}

Liu, Delong ^{[1
]}

Zhang, Wanbin ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Shanghai Inst Biomed & Pharmaceut Technol, 779 Laohumin Rd, Shanghai 200237, Peoples R China

[3] Shanghai Jiao Tong Univ, Frontier Sci Ctr Transformat Mol, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

TETRAHEDRON | 2023年 / 143卷

基金：

中国国家自然科学基金;

关键词：

RuPHOX-Ru; Asymmetric Guerbet reaction; Long-chain chiral alcohol; CHIRAL-GAMMA-LACTONES; TRANSFER HYDROGENATION; AMINO KETONES; IRIDIUM CATALYSTS; BETA-ALKYLATION; METHYL KETONES; METAL; LIGANDS; COMPLEXES; CYCLOALKANES;

D O I：

10.1016/j.tet.2023.133543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient RuPHOX-Ru catalyzed asymmetric Guerbet reaction of secondary alcohols with a broad scope of primary alcohols has been developed, affording long-chain chiral alcohols in high yields with excellent enantioselectivities (up to 99% yield and 96% ee). In particular, alkyl primary alcohols could also react to give the desired products with good results. The protocol could be performed on a gram-scale, providing an alternative pathway with minimal environmental impact and high atom-economy for the preparation of chiral alcohol products. & COPY; 2023 Elsevier Ltd. All rights reserved.

引用

页数：9

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