Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

被引：11

作者：

Birkner, Thomas ^{[1
,2
]}

Siegels, Doreen ^{[1
,2
]}

Heinrich, Luise ^{[1
,2
]}

Haufe, Eva ^{[1
,2
]}

Abraham, Susanne ^{[3
]}

Heratizadeh, Annice ^{[4
]}

Harder, Inken ^{[5
]}

Bell, Magnus ^{[6
]}

Fell, Isabell ^{[7
]}

Worm, Margitta ^{[8
]}

Handrick, Christiane ^{[9
]}

Effendy, Isaak ^{[10
]}

Asmussen, Andrea ^{[11
]}

Kleinheinz, Andreas ^{[12
]}

Homey, Bernhard ^{[13
]}

Sticherling, Michael ^{[14
]}

Hong-Weldemann, Sung-Hei ^{[15
]}

Augustin, Matthias ^{[16
]}

Weisshaar, Elke ^{[17
]}

Schaekel, Knut ^{[18
]}

Schaefer, Thomas ^{[19
]}

Schwarz, Beate ^{[20
]}

Wiemers, Franca ^{[21
]}

Bruecher, Jens-Joachim ^{[22
]}

Quist, Sven ^{[23
]}

Wollenberg, Andreas ^{[24
,25
]}

Biedermann, Tilo ^{[26
]}

Ertner, Konstantin ^{[27
]}

von Kiedrowski, Ralph ^{[28
,29
]}

Werfel, Thomas ^{[4
]}

Weidinger, Stephan ^{[5
]}

Schmitt, Jochen ^{[1
,2
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Evidence Based Healthcare, Fetscherstr 74, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Carl Gustav Carus Fac Med, Fetscherstr 74, D-01307 Dresden, Germany

[3] Tech Univ Dresden, Univ Allergy Ctr, Carl Gustav Carus Fac Med, Dept Dermatol, Dresden, Germany

[4] Hannover Med Sch, Dept Dermatol & Allergy, Hannover, Germany

[5] Univ Hosp Schleswig Holstein, Ctr Inflammatory Skin Dis, Dept Dermatol & Allergy, Campus Kiel, Kiel, Germany

[6] Practice Dr Med Magnus Bell, Andernach, Germany

[7] Hautmed Bad Soden Studienzentrum, Bad Soden, Germany

[8] Charite Univ Med Berlin, Dept Dermatol Allergy & Venereol, Berlin, Germany

[9] Practice Dr Med Christiane Handrick, Berlin, Germany

[10] OWL Univ Hosp Bielefeld Univ, Dept Dermatol, Campus Clin Bielefeld, Bielefeld, Germany

[11] Practice Dr Med Andrea Asmussen, Dermatol Lesum, Bremen, Germany

[12] Elbe Klinikum, Clin Dermatol, Buxtehude, Germany

[13] Univ Hosp Duesseldorf, Dept Dermatol & Allergol, Dusseldorf, Germany

[14] Univ Erlangen Nurnberg, German Ctr Immunotherapy, Dept Dermatol, Erlangen, Germany

[15] Practice Dr Med Sung Hei Hong Weldemann, Freiburg, Germany

[16] Univ Med Ctr Hamburg Eppendorf, Inst Hlth Serv Res Dermatol Hamburg, Hamburg, Germany

[17] Ruprecht Karls Univ Heidelberg, Dept Dermatol, Div Occupat Dermatol, Heidelberg, Germany

[18] Univ Hosp, Dept Dermatol, Heidelberg, Germany

[19] Practice Dr Med Thomas Schaefer, Derma Koeln, Dr Med Doreen Belz, Cologne, Germany

[20] Practice Dr Med Beate Schwarz, Langenau, Germany

[21] Practice Dr Med Franca Wiemers, Leipzig, Germany

[22] Practice Dr Med Jens Joachim Brucher, Hautambulatorium Magdeburg, Magdeburg, Germany

[23] Helix Med Excellence Ctr Mainz, Dermatol Clin, Mainz, Germany

[24] Ludwig Maximilians Univ Munchen, Clin & Outpatient Clin Dermatol & Allergy, Munich, Germany

[25] Vrije Univ Brussel, Univ Ziekenhuis, Dept Dermatol, Brussels, Belgium

[26] Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

[27] Practice Dr Med Konstantin Ertner, Nurnberg, Germany

[28] Focus Practice Chron Inflammatory Dermatoses Skin, Selters Westerwald, Germany

[29] Study Ctr CMS3 Co Med Study & Serv, Selters Westerwald, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2023年 / 21卷 / 10期

关键词：

Atopic dermatitis; productivity loss; registry; work limitations; HARMONIZING OUTCOME MEASURES; ORIENTED ECZEMA MEASURE; PARTY DIAGNOSTIC-CRITERIA; EUROPEAN TASK-FORCE; WORK LIMITATIONS; OBJECTIVE SCORAD; CONSENSUS REPORT; CLINICAL-TRIALS; MEASURE POEM; INDEX EASI;

D O I：

10.1111/ddg.15159

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BackgroundTREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled. MethodsIn TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated. ResultsThe examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60). ConclusionsThe analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.

引用

页码：1157 / 1168

页数：12

共 70 条

[1] Economic Burden of Adult Patients with Moderate to Severe Atopic Dermatitis Indicated for Systemic Treatment [J].

Ariens, Lieneke F. M. ;

van Nimwegen, Kirsten J. M. ;

Shams, Madan ;

de Bruin, Digna T. ;

van der Schaft, Jorien ;

van Os-Medendorp, Harmieke ;

De Bruin Weller, Marjolein .

ACTA DERMATO-VENEREOLOGICA, 2019, 99 (09) :762-768

[2] Characterization of the effects on pruritus by novel treatments for atopic dermatitis [J].

Bonnekoh, Hanna ;

Butze, Monique ;

Metz, Martin .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2022, 20 (02) :150-156

[3]

Bosma AL., 2022, J EUR ACAD DERMATOL, V00, P1

[4] Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) [J].

Chalmers, J. R. ;

Simpson, E. ;

Apfelbacher, C. J. ;

Thomas, K. S. ;

von Kobyletzki, L. ;

Schmitt, J. ;

Singh, J. A. ;

Svensson, A. ;

Williams, H. C. ;

Abuabara, K. ;

Aoki, V. ;

Ardeleanu, M. ;

Awici-Rasmussen, M. ;

Barbarot, S. ;

Berents, T. L. ;

Block, J. ;

Bragg, A. ;

Burton, T. ;

Clemmensen, K. K. Bjerring ;

Creswell-Melville, A. ;

Dinesen, M. ;

Drucker, A. ;

Eckert, L. ;

Flohr, C. ;

Garg, M. ;

Gerbens, L. A. A. ;

Graff, A. L. B. ;

Hanifin, J. ;

Heinl, D. ;

Humphreys, R. ;

Ishii, H. A. ;

Kataoka, Y. ;

Leshem, Y. A. ;

Marquort, B. ;

Massuel, M. -A. ;

Merhand, S. ;

Mizutani, H. ;

Murota, H. ;

Murrell, D. F. ;

Nakahara, T. ;

Nasr, I. ;

Nograles, K. ;

Ohya, Y. ;

Osterloh, I. ;

Pander, J. ;

Prinsen, C. ;

Purkins, L. ;

Ridd, M. ;

Sach, T. ;

Schuttelaar, M. -L. A. .

BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (01) :69-79

[5] Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods [J].

Charman, C. R. ;

Venn, A. J. ;

Ravenscroft, J. C. ;

Williams, H. C. .

BRITISH JOURNAL OF DERMATOLOGY, 2013, 169 (06) :1326-1332

[6] The patient-oriented eczema measure - Development and initial validation of a new tool for measuring atopic eczema severity from the patients' perspective [J].

Charman, CR ;

Venn, AJ ;

Williams, HC .

ARCHIVES OF DERMATOLOGY, 2004, 140 (12) :1513-1519

[7] Severity strata for Eczema Area and Severity Index (EASI), modified EASI, Scoring Atopic Dermatitis (SCORAD), objective SCORAD, Atopic Dermatitis Severity Index and body surface area in adolescents and adults with atopic dermatitis [J].

Chopra, R. ;

Vakharia, P. P. ;

Sacotte, R. ;

Patel, N. ;

Immaneni, S. ;

White, T. ;

Kantor, R. ;

Hsu, D. Y. ;

Silverberg, J. I. .

BRITISH JOURNAL OF DERMATOLOGY, 2017, 177 (05) :1316-1321

[8] Relationship between EASI and SCORAD severity assessments for atopic dermatitis [J].

Chopra, Rishi ;

Vakharia, Paras P. ;

Sacotte, Ryan ;

Patel, Neha ;

Immaneni, Supriya ;

White, Takeshia ;

Kantor, Robert ;

Hsu, Derek Y. ;

Silverberg, Jonathan I. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (06) :1708-+

[9]

Cohen J., 1988, Statistical Power Analysis for the Behavioral Sciences, V2nd, DOI 10.4324/9780203771587

[10] Disease burden and treatment history among adults with atopic dermatitis receiving systemic therapy: baseline characteristics of participants on the EUROSTAD prospective observational study [J].

de Bruin-Weller, Marjolein ;

Pink, Andrew E. ;

Patrizi, Annalisa ;

Gimenez-Arnau, Ana M. ;

Agner, Tove ;

Roquet-Gravy, Pierre-Paul ;

Ferrucci, Silvia M. ;

Arenberger, Petr ;

Svensson, Ake ;

Schuttelaar, Marie L. A. ;

Nosbaum, Audrey ;

Jayawardena, Shyamalie ;

Rizova, Elena ;

Ardeleanu, Marius ;

Eckert, Laurent ;

Ozturk, Zafer E. .

JOURNAL OF DERMATOLOGICAL TREATMENT, 2021, 32 (02) :164-173

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