The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease

被引：39

作者：

Abhishek, Abhishek ^{[1
]}

Tedeschi, Sara K. K. ^{[2
,3
]}

Pascart, Tristan ^{[4
]}

Latourte, Augustin ^{[5
,6
]}

Dalbeth, Nicola ^{[7
]}

Neogi, Tuhina ^{[8
]}

Fuller, Amy ^{[1
]}

Rosenthal, Ann ^{[9
]}

Becce, Fabio ^{[10
,11
]}

Bardin, Thomas ^{[5
,6
]}

Ea, Hang Korng ^{[5
,6
]}

Filippou, Georgios ^{[12
]}

FitzGerald, John ^{[13
]}

Iagnocco, AnnaMaria ^{[14
]}

Liote, Frederic ^{[15
,16
]}

McCarthy, Geraldine M. M. ^{[17
,18
]}

Ramonda, Roberta ^{[19
]}

Richette, Pascal

Sivera, Francisca ^{[20
,21
]}

Andres, Mariano ^{[22
]}

Cipolletta, Edoardo ^{[23
]}

Doherty, Michael ^{[1
]}

Pascual, Eliseo ^{[24
]}

Perez-Ruiz, Fernando ^{[25
,26
]}

So, Alexander ^{[10
]}

Jansen, Tim L. L. ^{[27
]}

Kohler, Minna J. J. ^{[3
,28
]}

Stamp, Lisa K. K. ^{[29
]}

Yinh, Janeth ^{[3
,28
]}

Adinolfi, Antonella ^{[30
]}

Arad, Uri ^{[31
]}

Aung, Thanda ^{[32
]}

Benillouche, Eva ^{[33
]}

Bortoluzzi, Alessandra ^{[34
,35
]}

Dau, Jonathan ^{[36
]}

Maningding, Ernest ^{[37
]}

Fang, Meika A. A. ^{[13
]}

Figus, Fabiana A. A. ^{[38
,39
]}

Filippucci, Emilio ^{[23
]}

Haslett, Janine ^{[29
]}

Janssen, Matthijs ^{[40
]}

Kaldas, Marian ^{[41
]}

Kimoto, Maryann ^{[41
]}

Leamy, Kelly ^{[18
]}

Navarro, Geraldine M. ^{[42
]}

Sarzi-Puttini, Piercarlo ^{[43
]}

Scire, Carlo ^{[44
]}

Silvagni, Ettore ^{[34
,35
]}

Sirotti, Silvia ^{[45
]}

Stack, John R. R. ^{[17
,18
]}

机构：

[1] Univ Nottingham, Acad Rheumatol, Nottingham, England

[2] Brigham & Womens Hosp, Div Rheumatol Inflammat & Immun, Boston, MA USA

[3] Harvard Med Sch, Boston, MA USA

[4] Lille Catholic Univ, St Philibert Hosp, Dept Rheumatol, Lille, France

[5] Univ Paris, UMR S 1132 BIOSCAR, INSERM, Paris, France

[6] Lariboisiere Hosp, AP HP, Serv Rhumatol, Paris, France

[7] Univ Auckland, Dept Med, Auckland, New Zealand

[8] Boston Univ, Dept Med, Sect Rheumatol, Sch Med, Boston, MA USA

[9] Med Coll Wisconsin, Dept Med, Milwaukee, WI USA

[10] Lausanne Univ Hosp, Lausanne, Switzerland

[11] Univ Lausanne, Lausanne, Switzerland

[12] IRCCS Ist Ortoped Galeazzi, Rheumatol Dept, Milan, Italy

[13] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

[14] Univ Torino, Acad Rheumatol Ctr, Turin, Italy

[15] Univ Paris, INSERM, Lariboisiere Hosp, AP HP,UMR S 1132 BIOSCAR,Serv Rhumatol, Paris, France

[16] Univ Paris Cite, Fac Sante, Paris, France

[17] Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland

[18] Mater Misericordiae Univ Hosp, Dublin, Ireland

[19] Univ Padua, Dept Med, Rheumatol Unit, Padua, Italy

[20] Hosp Gen Univ Elda, Dept Rheumatol, Elda, Spain

[21] Univ Miguel Hernandez, Dept Clin Med, Elche, Spain

[22] Univ Miguel Hernandez, Hosp Gen Univ Alicante, Dept Med, Rheumatol Sect, Alicante, Spain

[23] Polytech Univ Marche, Dept Clin & Mol Sci, Rheumatol Unit, Ancona, Italy

[24] Cruces Univ Hosp, Rheumatol Div, Bilbao, Spain

[25] Univ Basque Country, Biocruces Bizkaia Hlth Res Inst, Med & Nursing Sch, Dept Med,Arthrit Invest Grp, Bilbao, Spain

[26] Basque Country Rheumatol Soc, Bilbao, Spain

[27] VieCuri Med Ctr, Venlo, Netherlands

[28] Massachusetts Gen Hosp, Dept Med, Rheumatol Unit, Boston, MA USA

[29] Univ Otago, Dept Med, Christchurch, New Zealand

[30] Grande Osped Metropolitano Niguarda, Rheumatol Unit, Milan, Italy

[31] Te Whatu Ora Hlth New Zealand Waikato, Dept Rheumatol, Hamilton, New Zealand

[32] Univ Calif Los Angeles, Div Rheumatol, Los Angeles, CA USA

[33] Lausanne Univ Hosp, Dept Rheumatol, Lausanne, Switzerland

[34] Univ Ferrara, Dept Med Sci, Sect Rheumatol, Ferrara, Italy

[35] Azienda Osped Univ Ferrara, Cona, FE, Italy

[36] Massachusetts Gen Hosp, Dept Med, Rheumatol Unit, Boston, MA USA

[37] Highland Hosp, Oakland, CA USA

[38] Turin 3, Local Hlth Unit ASL, Rheumatol Div, Collegno, Italy

[39] Turin 3, Rheumatol Div, Local Hlth Unit ASL, Pinerolo, Italy

[40] VieCuri Med Ctr, Venlo, Netherlands

[41] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

[42] Univ Calif Los Angeles, Div Rheumatol, Los Angeles, CA USA

[43] IRCCS Galeazzi St Ambrogio Hosp, Dept Rheumatol, Milan, Italy

[44] Italian Soc Rheumatol, Epidemiol Unit, Milan, Italy

[45] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[46] Middlemore Hosp, Dept Med Gen Med & Rheumatol, Counties Manukau Hlth Dist, Auckland, New Zealand

[47] San Diego Vet Adm Healthcare Serv, San Diego, CA USA

[48] Univ Calif San Diego, San Diego, CA USA

来源：

ARTHRITIS & RHEUMATOLOGY | 2023年 / 75卷 / 10期

关键词：

RHEUMATOLOGY/EUROPEAN LEAGUE; CONVENTIONAL RADIOGRAPHY; RHEUMATOID-ARTHRITIS; AMERICAN-COLLEGE; PREVALENCE; CHONDROCALCINOSIS; IDENTIFICATION; OSTEOARTHRITIS; ASSOCIATION; ULTRASOUND;

D O I：

10.1002/art.42619

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease.Methods. Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de-identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi-criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort.Results. Among patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score >56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers).Conclusion. The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.

引用

页码：1703 / 1713

页数：11

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