The Level of Lipid Peroxidation Products and Medium-Molecular-Weight Peptides in Adolescents with Obesity

Background: The aim of this research was to study the plasma content of lipid peroxidation products and MMWP in obese adolescents.Materials and Results: The studies were conducted on 19 adolescent girls and 18 adolescent boys with an established diagnosis of exogenous constitutional obesity of the first degree. Twenty-four adolescent girls and 20 adolescent boys made up control groups. All adolescents were subjected to general clinical examination, including anamnestic data collection, physical examination, anthropometric data analysis, and nutritional status assessment. The content of primary, secondary, and final lipid peroxidation (LPO) products was evaluated, as well as medium-molecular-weight peptides (MMWP) absorbing at wavelengths 238, 254, and 280 nm by the spectrophotometric method.The group of obese adolescent girls, compared to the control, showed lower values of secondary LPO (thiobarbituric acid reactants) (P=0.022) and elevated levels of MMWP-238 (P<0.0001) and MMWP-280 (P=0.03). The group of obese adolescent boys, compared to the control, showed higher values of secondary LPO products (ketodienes and conjugated trienes) (P=0.042) and elevated levels of MMWP-238 (P=0.03).Conclusion: The obtained data demonstrate the presence of activation of lipid peroxidation processes at the stage of secondary products in adolescent boys and endogenous intoxication in obese adolescents, regardless of gender. The need to monitor and correct these indicators in adolescent patients with obesity should be an important component of pathogenetic