Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting

被引：8

作者：

McMahan, Rachel H. ^{[1
,2
,17
]}

Anton, Paige ^{[2
,3
]}

Coleman, Leon G. ^{[4
]}

Cresci, Gail A. M. ^{[5
,6
,7
]}

Crews, Fulton T. ^{[4
]}

Crotty, Kathryn M. ^{[8
,9
]}

Luck, Marisa E. ^{[10
]}

Molina, Patricia E. ^{[11
,12
]}

Vachharajani, Vidula ^{[13
]}

Weinberg, Joanne ^{[14
]}

Yeligar, Samantha M. ^{[8
,9
]}

Choudhry, Mashkoor A.

McCullough, Rebecca L. ^{[2
,3
,10
]}

Kovacs, Elizabeth J. ^{[1
,2
,15
,16
]}

机构：

[1] Univ Colorado, Dept Surg, Div GI Trauma & Endocrine Surg, Anschutz Med Campus, Aurora, CO USA

[2] Univ Colorado, Alcohol Res Program, Anschutz Med Campus, Aurora, CO USA

[3] Univ Colorado, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO USA

[4] Univ N Carolina, Bowles Ctr Alcohol Studies, Sch Med, Dept Pharmacol, Chapel Hill, NC USA

[5] Cleveland Clin, Childrens Hosp Inflammat Immun, Lerner Res Inst, Dept Pediat Gastroenterol, Cleveland, OH USA

[6] Cleveland Clin, Childrens Hosp Inflammat Immun, Lerner Res Inst, Dept Hepatol, Cleveland, OH USA

[7] Cleveland Clin, Childrens Hosp Inflammat Immun, Lerner Res Inst, Dept Nutr, Cleveland, OH USA

[8] Emory Univ, Dept Med, Div Pulm Allergy Crit Care & Sleep Med, Atlanta, GA USA

[9] Atlanta Vet Affairs Hlth Care Syst, Decatur, GA USA

[10] Loyola Univ Chicago, Burn Shock Trauma Res Inst, Stritch Sch Med, Dept Surg,Hlth Sci Div,Alcohol Res Program,Integra, Maywood, IL USA

[11] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA

[12] Louisiana State Univ, Comprehens Alcohol Res Ctr, Hlth Sci Ctr, New Orleans, LA USA

[13] Case Western Reserve Univ, Cleveland Clin, Lerner Res Inst, Resp Inst,Lerner Coll Med,Dept Inflammat & Immun,C, Cleveland, OH USA

[14] Univ British Columbia, Fac Med, Dept Cellular Physiol Sci, Vancouver, BC, Canada

[15] Univ Colorado Denver, Mol Biol Grad Program, Anschutz Med Campus, Aurora, CO USA

[16] Rocky Mt Reg Vet Affairs Med Ctr, Aurora, CO USA

[17] 12700 East 19th Ave,Res Complex 2,Mailstop 8620, Aurora, CO 80045 USA

来源：

ALCOHOL | 2023年 / 110卷

基金：

美国国家卫生研究院;

关键词：

advanced age; brain; epigenetics; ethanol; fetal programming; inflammation; intestine; lung; macrophage; metabolism; mitochondria; neurogenesis; T cell; NEUROIMMUNE; CONSUMPTION; INJURY; LUNG;

D O I：

10.1016/j.alcohol.2023.04.002

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

On October 26th, 2022 the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held as a satellite symposium at the annual meeting of the Society for Leukocyte Biology in Hawaii. The 2022 meeting focused broadly on the immunological consequences of acute, chronic, and prenatal alcohol exposure and how these contribute to damage in multiple organs and tissues. These included alcohol-induced neuroinflammation, impaired lung immunity, intestinal dysfunction, and decreased anti-microbial and anti-viral responses. In addition, research presented covered multiple pathways behind alcohol-induced cellular dysfunction, including mitochondrial metabolism, cellular bioenergetics, gene regulation, and epigenetics. Finally, the work presented highlighted potential biomarkers and novel avenues of treatment for alcohol-induced organ damage. Published by Elsevier Inc.

引用

页码：57 / 63

页数：7

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