The autophagy in ischemic stroke: A regulatory role of non-coding-RNAs

被引：16
作者：
Xiaoqing, Su [1 ]
Yinghua, Chen [1 ,4 ]
Xingxing, Yuan [2 ,3 ,5 ]
机构：
[1] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Acupuncture 5, Harbin 150040, Heilongjiang, Peoples R China
[2] Heilongjiang Univ tradit Chinese Med, Harbin 150040, Heilongjiang, Peoples R China
[3] Heilongjiang Acad tradit Chinese Med, Dept internal Med, Harbin 150001, Heilongjiang, Peoples R China
[4] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, 26 Heping St, Harbin 150040, Heilongjiang, Peoples R China
[5] Heilongjiang Acad tradit Chinese Med, 33 West Dazhi St, Harbin 150001, Heilongjiang, Peoples R China
来源：
CELLULAR SIGNALLING | 2023年 / 104卷
关键词：
Ischemic stroke; Autophagy; Non-coding RNA; Neuroprotection; Therapy; FOCAL CEREBRAL-ISCHEMIA; CELL-DEATH; ISCHEMIA/REPERFUSION INJURY; INHIBITING AUTOPHAGY; DEPENDENT AUTOPHAGY; NEURONAL AUTOPHAGY; REPERFUSION INJURY; UP-REGULATION; RAT MODEL; ACTIVATION;
D O I：
10.1016/j.cellsig.2022.110586
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ischemic stroke (IS) is a central nervous system neurological disorder ascribed to an acute focal trauma, with high mortality and disability, leading to a heavy burden on family and society. Autophagy is a self-digesting process by which damaged organelles and useless proteins are recycled to maintain cellular homeostasis, and plays a pivotal role in the process of IS. Non-coding RNAs (ncRNAs), mainly contains microRNA, long non-coding RNA and circular RNA, have been extensively investigated on regulation of autophagy in human diseases. Recent studies have implied that ncRNAs-regulating autophagy participates in pathophysiological process of IS, including cell apoptosis, inflammation, oxidative stress, blood-brain barrier damage and glial activation, which indicates that regulating autophagy by ncRNAs may be beneficial for IS treatment. This review summarizes the role of autophagy in IS, as well as focuses on the role of ncRNAs-mediated autophagy in IS, for the development of potential therapeutic strategies in this disease.
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页数：10
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