Neoadjuvant chemotherapy for early-stage colon cancer

被引：21

作者：

Audisio, Alessandro ^{[1
]}

Fazio, Roberta ^{[1
]}

Dapra, Valentina ^{[1
]}

Assaf, Irene ^{[1
,2
]}

Hendlisz, Alain ^{[1
,2
]}

Sclafani, Francesco ^{[1
,2
,3
]}

机构：

[1] Brussels Univ Hosp HUB, Inst Jules Bordet, Brussels, Belgium

[2] Univ Libre Brussels ULB, Brussels, Belgium

[3] Inst Jules Bordet, Dept Digest Oncol, Rue Meylemeersch 90, B-1070 Brussels, Belgium

来源：

CANCER TREATMENT REVIEWS | 2024年 / 123卷

关键词：

Colon cancer; Neoadjuvant chemotherapy; pMMR/MSS; RANDOMIZED PHASE-III; ADJUVANT TREATMENT; RECTAL-CANCER; OPEN-LABEL; PREOPERATIVE CHEMORADIOTHERAPY; PERIOPERATIVE CHEMOTHERAPY; MISMATCH REPAIR; FLUOROURACIL; OXALIPLATIN; LEUCOVORIN;

D O I：

10.1016/j.ctrv.2023.102676

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Surgery with or without adjuvant chemotherapy is the standard treatment for early-stage colon cancer. However, evidence has recently emerged for neoadjuvant chemotherapy, with the results of randomised clinical trials sparking debates within multidisciplinary teams and splitting the gastrointestinal oncology community. Further to a systematic search of the literature, we provide a thorough and in-depth analysis of the findings from these trials, highlighting the advantages and disadvantages of neoadjuvant chemotherapy. We conclude that, while there is a potential value of moving systemic therapy from the post-operative to the pre-operative setting, the available evidence does not justify a shift in the treatment paradigm of early-stage colon cancer, and surgery with or without adjuvant chemotherapy should remain the standard approach for these patients.

引用

页数：9

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