SO2ClF-Promoted Chlorooxidation of Tryptamine Derivatives: Synthesis of 3,3-Disubstituted Oxindoles

被引：1

作者：

Zheng, Yu ^{[1
]}

Lu, Wenguang ^{[1
]}

Ma, Tianting ^{[1
]}

Huang, Shenlin ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat, Forest Resources Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

3-chlorooxindoles; tryptamine derivatives; chlorooxidation; 3,3-disubstituted oxindoles; gram-scale reaction; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE BROMOCYCLIZATION; 3-BROMOOXINDOLES; CONSTRUCTION; ALKYLATION; 3-CHLOROOXINDOLES; TRANSFORMATION; CHLORINATION; ANNULATION; CHLORIDE;

D O I：

10.1002/ajoc.202300552

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of tryptamine derivatives were transformed into their corresponding 3-chloro-2-oxidation products under simple and mild conditions. This protocol is an operationally simple system that utilizes a single reagent SO2ClF plays a dual role as both oxidant and chloride source and enables the construction of various 3,3-disubstituted oxindoles with good functional group tolerance. The transformations of the product highlight its potential synthetic applications.

引用

页数：5

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